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Table 1 Drug recoveries in ex vivo circuits and controls relative to baseline and their relationship to lipophilicity and protein-binding characteristicsa

From: Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study

Drug Mean (SD) drug recovery (%) from controls at 24 hr Mean (SD) drug recovery (%) from circuits at 24 hr Lipophilicity (log P ) Protein binding (%)
Ciprofloxacin 119 (4) 96 (17) 2.3 20 to 40
Fluconazole 102 (1) 91 (4) 0.4 12
Linezolid 102 (4) 91 (4) 0.9 31
Ceftriaxone 102 (1) 80 (6) −1.7 95
Caspofungin 99 (8) 56 (13) 0.1 97
Thiopentone 102 (8) 12 (5) 2.3 80
Fentanyl* 82 (6.3) 3 (3.8) 3.9 85
Midazolam* 100 (3.6) 13 (2) 3.9 92
Meropenem* 42 (1.5) 20 (7) −0.6 2
Vancomycin* 98 (9) 91 (11) −3.1 55
Morphine* 103 (11) 97 (2.6) 0.8 30
  1. aLog P, Log; SD, Standard deviation. Drugs that are significantly lost in the extracorporeal membrane oxygenation circuit are highlighted. Asterisks indicate previously published data from the same experiment [5].