Skip to main content

Table 1 Drug recoveries in ex vivo circuits and controls relative to baseline and their relationship to lipophilicity and protein-binding characteristicsa

From: Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study

Drug

Mean (SD) drug recovery (%) from controls at 24 hr

Mean (SD) drug recovery (%) from circuits at 24 hr

Lipophilicity (log P )

Protein binding (%)

Ciprofloxacin

119 (4)

96 (17)

2.3

20 to 40

Fluconazole

102 (1)

91 (4)

0.4

12

Linezolid

102 (4)

91 (4)

0.9

31

Ceftriaxone

102 (1)

80 (6)

−1.7

95

Caspofungin

99 (8)

56 (13)

0.1

97

Thiopentone

102 (8)

12 (5)

2.3

80

Fentanyl*

82 (6.3)

3 (3.8)

3.9

85

Midazolam*

100 (3.6)

13 (2)

3.9

92

Meropenem*

42 (1.5)

20 (7)

−0.6

2

Vancomycin*

98 (9)

91 (11)

−3.1

55

Morphine*

103 (11)

97 (2.6)

0.8

30

  1. aLog P, Log; SD, Standard deviation. Drugs that are significantly lost in the extracorporeal membrane oxygenation circuit are highlighted. Asterisks indicate previously published data from the same experiment [5].
Back to article page

Critical Care

ISSN: 1364-8535