|
Drug
|
Mean (SD) drug recovery (%) from controls at 24 hr
|
Mean (SD) drug recovery (%) from circuits at 24 hr
|
Lipophilicity (log
P
)
|
Protein binding (%)
|
|---|
|
Ciprofloxacin
|
119 (4)
|
96 (17)
|
2.3
|
20 to 40
|
|
Fluconazole
|
102 (1)
|
91 (4)
|
0.4
|
12
|
|
Linezolid
|
102 (4)
|
91 (4)
|
0.9
|
31
|
|
Ceftriaxone
|
102 (1)
|
80 (6)
|
−1.7
|
95
|
|
Caspofungin
|
99 (8)
|
56 (13)
|
0.1
|
97
|
|
Thiopentone
|
102 (8)
|
12 (5)
|
2.3
|
80
|
|
Fentanyl*
|
82 (6.3)
|
3 (3.8)
|
3.9
|
85
|
|
Midazolam*
|
100 (3.6)
|
13 (2)
|
3.9
|
92
|
|
Meropenem*
|
42 (1.5)
|
20 (7)
|
−0.6
|
2
|
|
Vancomycin*
|
98 (9)
|
91 (11)
|
−3.1
|
55
|
|
Morphine*
|
103 (11)
|
97 (2.6)
|
0.8
|
30
|
-
aLog P, Log; SD, Standard deviation. Drugs that are significantly lost in the extracorporeal membrane oxygenation circuit are highlighted. Asterisks indicate previously published data from the same experiment [5].
