From: Inhaled nitric oxide therapy and risk of renal dysfunction: a systematic review and meta-analysis of randomized trials
Protocols of iNO
Valvini (1995) 
40 ppm for 3 days followed by 90 ppm for 2 days
1. Inhaling 40 ppm nitric oxide would result in a daily nitrogen oxide load of about 25 mmol.
2. Impairment of renal function would cause an increase in serum nitrogen oxides.
Troncy (1997) 
40 ppm iNO
Inhaled nitric oxide increased renal blood flow, glomerular filtration rate and urinary flow.
Preiser (1998) 
1 to 20 ppm
1. Renal excretion of NO2 − and NO3 − was unaltered by nitric oxide inhalation.
2. Long-term nitric oxide inhalation was associated with a consistent increase in the NO3 − plasma concentration.
Wraight (2001) 
40 ppm for 2 h
Inhaled nitric oxide may alter tubular salt and water resorbtion.
Kielbasa (2001) 
49 or 107 ppm iNO for 4 h
High dose of iNO increased nitric oxide synthase III protein expression, and nitrotyrosine and phosphotyrosine immunoreactivity.
Da (2007) 
30 ppm iNO for 3.5 h
Decreased swelling and necrosis of glomeruli.
Gozdzik (2009) 
40 ppm iNO for 30 h
1. Transient natriuretic effect.
2. Renal tubular apoptosis promotion after 30 h of iNO treatment.
Göranson (2014) 
30 ppm iNO for 30 h
Combined therapy with iNO and intravenous steroid is associated with partial protection of kidney function.