Study (year) | Species | Protocols of iNO | Main findings |
---|---|---|---|
Valvini (1995) [38] | Human | 40 ppm for 3 days followed by 90 ppm for 2 days | 1. Inhaling 40 ppm nitric oxide would result in a daily nitrogen oxide load of about 25 mmol. |
2. Impairment of renal function would cause an increase in serum nitrogen oxides. | |||
Troncy (1997) [9] | Swine | 40 ppm iNO | Inhaled nitric oxide increased renal blood flow, glomerular filtration rate and urinary flow. |
Preiser (1998) [37] | Human | 1 to 20 ppm | 1. Renal excretion of NO2 − and NO3 − was unaltered by nitric oxide inhalation. |
2. Long-term nitric oxide inhalation was associated with a consistent increase in the NO3 − plasma concentration. | |||
Wraight (2001) [36] | Human | 40 ppm for 2 h | Inhaled nitric oxide may alter tubular salt and water resorbtion. |
Kielbasa (2001) [35] | Rat | 49 or 107 ppm iNO for 4 h | High dose of iNO increased nitric oxide synthase III protein expression, and nitrotyrosine and phosphotyrosine immunoreactivity. |
Da (2007) [34] | Swine | 30 ppm iNO for 3.5 h | Decreased swelling and necrosis of glomeruli. |
Gozdzik (2009) [33] | Swine | 40 ppm iNO for 30 h | 1. Transient natriuretic effect. |
2. Renal tubular apoptosis promotion after 30 h of iNO treatment. | |||
Göranson (2014) [44] | Swine | 30 ppm iNO for 30 h | Combined therapy with iNO and intravenous steroid is associated with partial protection of kidney function. |