Skip to main content

Table 2 Baseline characteristics of the study patients according to survivala

From: Paracetamol therapy and outcome of critically ill patients: a multicenter retrospective observational study

  Survivors, N =13,654 Dead, N =2,164 P -value
Age, yr 63 (50–73) 67 (55–76) <0.001
Male sex 65% (8827) 63% (1372) 0.26
 APACHE II score 15.46 (5.78) 26.15 (8.13) <0.001
 SAPS II score 26.9 (20.6) 45.5 (26.1)) <0.001
Hospital A 21% (2870) 15% (335) <0.001
Hospital B 11% (1474) 11% (244) 0.5
Hospital C 10%(1300) 14% (307) <0.001
Hospital D 59%(8010) 59% (1278) 0.73
Mechanical ventilationb 71% (9694) 84% (1819) <0.001
Acute renal failurec 71% (9694) 84% (1819) <0.001
Surgical admissionsd 4% (572) 17% (362) <0.001
Elective surgery 69% (9398) 28% (596) <0.001
Infection as admission diagnosise 55% (7507) 9% (200) <0.001
 Number of temperature measurements 8% (1027) 18% (392) <0.001
 Mean temperature, °C 36.7 (0.6) 36.6 (1.0) <0.001
 Highest temperature, °C 37.6 (0.9) 37.9 (1.4) <0.001
 Lowest temperature, °C 35.5 (2.1) 34.9 (2.6) <0.001
 SD of temperature, °C 0.60 (0.45) 0.78 (0.49) <0.001
Temperature >38°Cf 26% (3469) 45% (928) <0.001
Temperature >38.3°Cf 18% (2441) 36% (771) <0.001
Temperature >38.5°Cf 13% (1812) 30% (644) <0.001
Temperature >39°Cf 6% (859) 18% (388) <0.001
Temperature <35°Cf 35% (4823) 52% (1126) <0.001
Number of patients given paracetamol 66% (9050) 46% (996) <0.001
 Total dose, g 0 (0–0) 3 (2–7) <0.001
 Mean daily dose,g g 0 (0–0) 1.9 (1.0-2.6) <0.001
  1. aAPACHE, Acute Physiology and Chronic Health Evaluation; SAPS, Simplified Acute Physiology Score; SD, Standard deviation; bMechanical ventilation within first 24 hours of ICU admission; c24 hour urine output is <410 ml AND creatinine >133 μmol/L AND patient is not receiving chronic dialysis. dAPACHE III-J principal postoperative diagnosis. eA list of admission diagnosis with infection is provided in Additional file 1. fIndicates the presence of a given temperature at any time during intensive care unit stay. gMean daily dose calculated by dividing total dose by number by treatment days.