Doubling survival and improving clinical outcomes using a left ventricular assist device instead of chest compressions for resuscitation after prolonged cardiac arrest: a large animal study

Table 1 Hemodynamics and blood gas data^a

		BL	PR 10	PR 30	PR 60	PR 120
		sCPR, n =10	sCPR, n =5	sCPR, n =5	sCPR, n =5	sCPR, n =5
		iCPR, n =10	iCPR, n =10	iCPR, n =10	iCPR, n =10	iCPR, n =10
HR (bpm)	sCPR	109 ± 28	160 ± 23	169 ± 20	139 ± 21	115 ± 27
	iCPR	85 ± 25	162 ± 36	149 ± 32	112 ± 23	92 ± 12
MAP (mmHg)	sCPR	100 ± 15	94 ± 26	77 ± 29	84 ± 24	80 ± 18
	iCPR	96 ± 10	85 ± 22	88 ± 13	80 ± 18	89 ± 22
CO (L/min)	sCPR	5.8 ± 1.0	5.2 ± 1.9	5.5 ± 2.5	4.2 ± 1.9	3.1 ± 1.2
	iCPR	4.6 ± 1.1	6.1 ± 0.9	4.8 ± 0.7	3.2 ± 0.8	3.6 ± 1.2
MPAP (mmHg)	sCPR	19 ± 3	20 ± 3	19 ± 3	21 ± 3	20 ± 2
	iCPR	18 ± 3	19 ± 5	19 ± 2	20 ± 3	18 ± 4
PaO₂ (mmHg)	sCPR	100 ± 10	520 ± 33	511 ± 64	104 ± 21	118 ± 26
	iCPR	107 ± 11	447 ± 90	433 ± 109	159 ± 76	136 ± 28
PaCO₂ (mmHg)	sCPR	38 ± 3	41 ± 6	39 ± 3	39 ± 1	39 ± 3^b
	iCPR	36 ± 3	42 ± 7	38 ± 6	35 ± 8	31 ± 4^b
Lactate (mmol/L)	sCPR	2.7 ± 2.0	9.6 ± 3.3	9.2 ± 2.7	7.3 ± 2.8	4.6 ± 2.4
	iCPR	1.7 ± 0.8	8.1 ± 1.7	8.0 ± 2.2	7.5 ± 1.9	6.2 ± 3.2
Glucose (mmol/L)	sCPR	117 ± 19	309 ± 66	290 ± 83	241 ± 78	193 ± 57
	iCPR	129 ± 25	242 ± 76	225 ± 77	208 ± 61	178 ± 48
pH	sCPR	7.48 ± 0.03	7.27 ± 0.09	7.30 ± 0.05	7.35 ± 0.06	7.40 ± 0.05
	iCPR	7.46 ± 0.03	7.27 ± 0.09	7.30 ± 0.08	7.36 ± 0.07	7.44 ± 0.08

^aHemodynamic and blood gas data in 20 pigs treated either with standard cardiopulmonary resuscitation (sCPR; n =10) or an intravascular CPR device (iCPR; n =10) at baseline (BL) or 10 (PR10), 30 (PR30), 60 (PR60) or 120 (PR120) minutes following return of spontaneous circulation. All animals received a bolus dose of 30 μg/kg epinephrine intravenously twice during CPR. HR, Heart rate; MAP, Mean arterial pressure; CO, Cardiac output; MPAP, Mean pulmonary artery pressure; PaO₂, Arterial oxygen tension; PaCO₂, Arterial carbon dioxide tension. Mean ± standard deviation. ^b P ≤0.01, iCPR vs. sCPR.

ISSN: 1364-8535