Central venous-to-arterial carbon dioxide difference combined with arterial-to-venous oxygen content difference is associated with lactate evolution in the hemodynamic resuscitation process in early septic shock

Table 2 Patients’ main characteristics according to ICU survival

	Survivors ( n = 25)	Nonsurvivors ( n = 10)	P value
Age (years)	65 ± 13	67 ± 13	0.6
SAPS II	47 ± 10	53 ± 12	0.5
SOFA (day 1)	9 ± 3	9 ± 3	0.7
Heart rate (beats per minute)	103 ± 15	103 ± 12	0.9
MAP (mmHg)	81 ± 11	69 ± 12	0.07
Norepinephrine dose (mcg/kg/min)	0.85 ± 0.65	0.93 ± 0.73	0.7
Hemoglobin (g/dl)	11.7 ± 1.8	9.6 ± 2.1	0.1
S_cvO₂ (%)	71 ± 9	71 ± 6	0.9
Lactate (mg/dl)	25 ± 10	69 ± 83	0.8
P_cvaCO₂ gap (mmHg)	5.4 ± 2.3	6.0 ± 1.5	0.3
P_cvaCO₂/C_avO₂ ratio (mmHg · dl/ml O₂)	1.4 ± 0.5	1.9 ± 0.9	0.03
ΔSOFA (day 4)	–3 ± 3	1 ± 4	0.02

Data presented as mean ± standard deviation or number (%). Main characteristics at inclusion are shown. During the follow-up period, the SOFA evolution within 4 days was also associated with higher mortality rates. MAP, mean arterial pressure; P_cvaCO₂ gap, central venous-to-arterial carbon dioxide difference; P_cvaCO₂/C_avO₂ ratio, central venous-to-arterial carbon dioxide difference/arterial-to-central venous oxygen content difference ratio; SAPS, Simplified Acute Physiological Score; ScvO₂, central venous oxygen saturation; ΔSOFA, SOFA score at day 4 – SOFA score at day 1; SOFA, sequential Organ Failure Assessment.

ISSN: 1364-8535