Skip to main content

Table 1 Alternative anticoagulation in heparin-induced thrombocytopenia [115-119]

From: Renal replacement therapy in acute kidney injury: controversy and consensus

  Danaparoid Bivalirudin Argatroban
Dosing 3,500 IU bolus, followed by 100 units/hour or 140 IU/hour without bolus 0.03-0.2 mg/kg per hour Bolus 100 μg/kg followed by 0.1-0.5 μg/kg per minute
Monitoring Anti-Xa activity 0.25-0.35 IU/mL (0.5-1.0 IU/mLa) Target aPTT ratio 1.5 (−2.5a) Target aPTT ratio 1.5 (−3.0a)
Main adverse events Cross-reactivity with HIT-ab No data Anemia; accumulation in liver failure
  1. aIf systemic anticoagulation is required. aPTT, activated partial thromboplastin time; HIT-ab, heparin-incuded thrombocytopenia antibody.