Renal replacement therapy in acute kidney injury: controversy and consensus

Table 1 Alternative anticoagulation in heparin-induced thrombocytopenia [115-119]

	Danaparoid	Bivalirudin	Argatroban
Dosing	3,500 IU bolus, followed by 100 units/hour or 140 IU/hour without bolus	0.03-0.2 mg/kg per hour	Bolus 100 μg/kg followed by 0.1-0.5 μg/kg per minute
Monitoring	Anti-Xa activity 0.25-0.35 IU/mL (0.5-1.0 IU/mL^a)	Target aPTT ratio 1.5 (−2.5^a)	Target aPTT ratio 1.5 (−3.0^a)
Main adverse events	Cross-reactivity with HIT-ab	No data	Anemia; accumulation in liver failure

^aIf systemic anticoagulation is required. aPTT, activated partial thromboplastin time; HIT-ab, heparin-incuded thrombocytopenia antibody.

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