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Table 2 Crude hazard ratio of COPD patients’ serious events

From: Gastro-oesophageal reflux disease increases the risk of intensive care unit admittance and mechanical ventilation use among patients with chronic obstructive pulmonary disease: a nationwide population-based cohort study

Factor

ICU admittance

Ventilator used

Hazard ratio

95% CI

Hazard ratio

95% CI

Without GORD

Reference

Reference

With GORD

1.67

1.22 to 2.27***

1.85

1.31 to 2.62***

Male

1.12

0.8 to 1.56

1.18

0.81 to 1.72

Age 40 to 50

Reference

Reference

Age 51 to 60

3.48

1.31 to 9.28*

1.48

0.58 to 3.76

Age 61 to 70

6.6

2.62 to 16.6***

3.64

1.62 to 8.2***

Age 71 to 80

9.92

4.00 to 24.6***

5.02

2.27 to 11.1***

Age ≥80

12.2

4.66 to 31.8***

8.99

3.9 to 20.7***

CCI = 0

Reference

Reference

CCI = 1 to 3

1.77

0.24 to 12.9

1.59

0.22 to 11.6

CCI = 4 to 6

3.09

0.43 to 22.4

2.3

0.32 to 16.8

CCI ≥7

9.59

1.33 to 68.9*

7.13

0.99 to 51.5

Theophylline used

1.26

0.77 to 2.06

1.87

0.98 to 3.57

Proxy COPD severity

2.24

1.21 to 4.12**

1.48

0.65 to 3.37

Residential area

 

 Urban

Reference

Reference

 Suburban

1.32

0.95 to 1.82

1.55

1.08 to 2.23

 Rural

0.89

0.50 to 1.60

1.14

0.61 to 2.12

Occupation categories

 

 Category 1

Reference

Reference

 Category 2

1.13

0.77 to 1.66

1.6

1.01 to 2.55*

 Category 2

1.28

0.84 to 1.94

1.76

1.07 to 2.90*

Monthly insurance premium ($NT)a

 No fee

Reference

Reference

 1to 19,199

0.76

0.51 to 1.12

1.04

0.67 to 1.61

 19,200 to 23,999

0.63

0.43 to 0.92*

0.77

0.5 to 1.2

  ≥ 24,000

0.29

0.15 to 0.56***

0.24

0.1 to 0.56***

  1. CCI, Charlson Comorbidity Index; CI, confidence interval; COPD, chronic obstructive pulmonary disease; GORD, gastro-esophageal reflux disease; NT, new Taiwan dollar. *P <0.05, **P <0.01, ***P <0.0001. aUS$1 ≒ $NT30.