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Table 1 Patient characteristics

From: Short-term amino acid infusion improves protein balance in critically ill patients

 

Pilot study (n =6)

Q1 effect AA (n =13)

Q2 time effect basal (n =10, subgroup of Q1)

Q3 time effect AA (n =7, subgroup of Q2)

First study day

First study day

Second study day

First study day

Second study day

Age, yr

70 (61 to 79)

69 (46 to 77)

71 (46 to 77)

71 (46 to 77)

Sex, male/female

3/3

8/5

6/4

4/3

Weight, kg

75 (63 to 95)

85 (42 to 146)

92 (70 to 146)

81 (70 to 138)

Diagnosis, medical/surgical

2/4

7/6

4/6

3/4

SAPS III

73 (41 to 76)

70 (54 to 93)

70 (54 to 93)

73 (54 to 93)

Days in ICU

4 (3 to 48)

5 (3 to 7)

4 (3 to 6)

7 (5 to 10)*

4 (3 to 6)

7 (5 to 10)*

SOFA score on study day

8 (1 to 12)

7 (2 to 14)

6 (2 to 14)

7 (2 to 15)

7 (3 to 14)

5 (2 to 15)

  1. Characteristics for the patients included in the pilot study and the different cohorts to evaluate the three research questions (Q1 through Q3). Q1: Do extra parenteral amino acids (AA) during the first week in the intensive care unit (ICU) modulate whole-body protein kinetics? Q2: Do baseline protein kinetics change during early ICU treatment? Q3: Are the effects of extra parenteral amino acids maintained after a few days? *Significantly different from first study day in same cohort (P <0.05 by Wilcoxon signed-rank test). SAPS III, Simplified Acute Physiology Score III; SOFA, Sequential Organ Failure Assessment.