Table 1 Baseline characteristics and copeptin and cortisol levels of out-of-hospital cardiac arrest patients and short-term and long-term outcomes
ICU non-survivors (n = 49) | ICU survivors (n = 229) | P value | Poor 12-month outcome (n = 143) | Good 12-month outcome (n = 133) | P value | |
|---|---|---|---|---|---|---|
Patient factors | ||||||
Age, years | 64±14 | 63±12 | 0.191 | 65 (±13) | 60 (±12) | 0.0017 |
Male,% (n) | 82% (40) | 83% (189) | 0.881 | 83% (119) | 82% (109) | 0.782 |
Factors at resuscitation | ||||||
Shockable,% (n) | 35% (17) | 71 (163) | <0.001 | 50% (71) | 81% (108) | <0.001 |
Time to ROSC, minutes | 24 (20–31) | 18 (12–26) | <0.001 | 23 (18-30) | 16 (11-23) | <0.001 |
Adrenaline used, yes | 92% (45) | 62% (141) | <0.001 | 83% (118) | 50% (67) | <0.001 |
ICU treatment | ||||||
Therapeutic hypothermia,% (n) | 59% (29) | 76% (173) | 0.020 | 68% (97) | 78% (104) | 0.053 |
Lowest 24-hour MAP, mm Hg | 58 (41–64) | 62 (58–68) | <0.001 | 61 (55–67) | 61 (57–68) | 0.241 |
Highest 24-hour norepinephrine, μg/kg per minute | 0.18 (0–0.35) | 0.06 (0–0.13) | <0.001 | 0.07(0–0.19) | 0.05 (0–0.14) | 0.409 |
SAPS II | 73 (64–81) | 57 (39–66) | <0.001 | 66 (57–73) | 48 (34–63) | <0.001 |
Biomarkers | ||||||
Copeptin 0–6 hours, pmol/L | 148 (58–291) | 63 (32–131) | 0.0009 | 89 (41–193) | 51 (29–111) | 0.0014 |
Copeptin 48 hours, pmol/L | 20 (9–111) | 20 (11–40) | 0.3399 | 23 (13–44) | 16 (10–46) | 0.0702 |
Relative change in copeptin | −45 (−166-(−13)) | −38 (−100-(−11)) | 0.502 | −44 (−142-(−13)) | −32 (−88-(7)) | 0.152 |
Cortisol 0–6 hours, nmol/L | 860 (627–1,119) | 634 (378–876) | 0.0006 | 728 (522–1,017) | 576 (355–850) | 0.0013 |
Cortisol 48 hours, nmol/L | 627 (311–1,461) | 548 (378–813) | 0.4414 | 645 (403–942) | 480 (328–733) | 0.0053 |
Change in cortisol,% | −115 (−592-253) | −62 (−329-192) | 0.419 | −59 (−343-215) | −65 (−331-194) | 0.741 |