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Table 2 Inflammatory cytokines in critically ill patients before and after a transfusion of fresh frozen plasma (12 ml/kg)

From: Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial

  Before FFP After FFP P value
Proinflammatory parameters (pg/ml)
TNF-α 11.3 (2.3–52.3) 2.3 (2.3–41.0) 0.01
IL-1β 15.0 (11.7–18.8) 14.4 (13.1–23.3) 0.97
IL-8 178 (124–418) 187 (113–412) 0.23
MCP-1 1255 (503–3376) 1101 (434–5802) 0.89
MIP-1A 19.6 (15.7–33.6) 19.1 (13.3–34.4) 0.12
sCD40L 409 (257–614) 324 (216–537) 0.08
Anti-inflammatory parameters (pg/ml)
IL-1RA 69.3 (52.1–110.6) 73.5 (47.8–104.9) 0.11
IL-10 36.1 (15.5–100.1) 31.5 (14.8–279.6) 0.62
  1. Data expressed as median (IQR). FFP, fresh frozen plasma; TNF-α, tumor necrosis factor alpha; IL-1β, interleukin 1 beta; IL-8, interleukin 8; MCP-1, monocyte chemotactic protein 1; MIP-1A, macrophage inflammatory proteins 1A; sCD40L, soluble CD40 ligand; IL-1RA, interleukin 1 receptor antagonist; IL-10, interleukin 10; IQR, interquartile range.