Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial

Table 2 Inflammatory cytokines in critically ill patients before and after a transfusion of fresh frozen plasma (12 ml/kg)

	Before FFP	After FFP	P value
*Proinflammatory parameters (pg/ml)*
TNF-α	11.3 (2.3–52.3)	2.3 (2.3–41.0)	0.01
IL-1β	15.0 (11.7–18.8)	14.4 (13.1–23.3)	0.97
IL-8	178 (124–418)	187 (113–412)	0.23
MCP-1	1255 (503–3376)	1101 (434–5802)	0.89
MIP-1A	19.6 (15.7–33.6)	19.1 (13.3–34.4)	0.12
sCD40L	409 (257–614)	324 (216–537)	0.08
*Anti-inflammatory parameters (pg/ml)*
IL-1RA	69.3 (52.1–110.6)	73.5 (47.8–104.9)	0.11
IL-10	36.1 (15.5–100.1)	31.5 (14.8–279.6)	0.62

Data expressed as median (IQR). FFP, fresh frozen plasma; TNF-α, tumor necrosis factor alpha; IL-1β, interleukin 1 beta; IL-8, interleukin 8; MCP-1, monocyte chemotactic protein 1; MIP-1A, macrophage inflammatory proteins 1A; sCD40L, soluble CD40 ligand; IL-1RA, interleukin 1 receptor antagonist; IL-10, interleukin 10; IQR, interquartile range.

ISSN: 1364-8535