From: Effects of terlipressin as early treatment for protection of brain in a model of haemorrhagic shock
Baseline | Shock | After treatment (min) | ||||||
---|---|---|---|---|---|---|---|---|
5 | 30 | 60 | 90 | 120 | ||||
PaCO2 (mmHg) | ||||||||
Sham | 47 ± 0 | 43 ± 3 | 41 ± 2 | 42 ± 1 | 42 ± 0 | 40 ± 0 | 41 ± 1 | |
HAEMO | 42 ± 3 | 39 ± 4 | 35.6 ± 7* | 43 ± 8 | 38 ± 6 | 38 ± 8 | 38 ± 8 | |
LR | 42 ± 4 | 38 ± 4 | 42.3 ± 3 | 41 ± 3 | 40 ± 2 | 39 ± 2 | 39 ± 2 | |
TERLI | 43 ± 2 | 42 ± 4 | 42.9 ± 5† | 47 ± 6† | 48 ± 7† | 45 ± 4† | 44 ± 5 | |
DO2I (ml/min/m2) | ||||||||
Sham | 540 ± 2 | 571 ± 107 | 501 ± 105 | 522 ± 108 | 553 ± 64 | 543 ± 95 | 518 ± 131 | |
HAEMO | 597 ± 81 | 243 ± 52* | 212 ± 64* | 190 ± 37* | 192 ± 38* | 194 ± 46* | 190 ± 37* | |
LR | 580 ± 61 | 237 ± 73* | 400 ± 49*† | 375 ± 62*† | 361 ± 66*† | 344 ± 64*† | 339 ± 59*† | |
TERLI | 581 ± 96 | 238 ± 27* | 288 ± 19* | 307 ± 43*† | 313 ± 51*† | 302 ± 55*† | 299 ± 73*† | |
VO2I (ml/min/m2) | ||||||||
Sham | 121 ± 3 | 140 ± 17 | 126 ± 28 | 133 ± 13 | 139 ± 9 | 133 ± 21 | 143 ± 24 | |
HAEMO | 126 ± 27 | 154 ± 36 | 139 ± 40 | 119 ± 20 | 123 ± 39 | 126 ± 27 | 122 ± 21 | |
LR | 129 ± 33 | 152 ± 38 | 173 ± 37* | 176 ± 24*† | 182 ± 30*† | 178 ± 24*† | 187 ± 33*† | |
TERLI | 123 ± 19 | 152 ± 21 | 161 ± 8* | 174 ± 22*† | 176 ± 23*† | 172 ± 23*† | 170 ± 24*† | |
K+ (mmol/L) | ||||||||
Sham | 4.4 ± 0.3 | 4.3 ± 0.0 | 4.0 ± 0.1 | 4.3 ± 0.1 | 4.4 ± 0.1 | 4.4 ± 0.5 | 4.5 ± 0.3 | |
HAEMO | 4.3 ± 0.4 | 5.6 ± 0.9* | 5.2 ± 0.9 | 5.7 ± 0.9* | 5.8 ± 0.8* | 6.0 ± 0.6* | 6.2 ± 0.5* | |
LR | 3.9 ± 0.2 | 5.8 ± 1.5* | 4.0 ± 0.3† | 4.4 ± 0.4† | 4.9 ± 0.6*† | 5.2 ± 0.7* | 5.1 ± 1.1* | |
TERLI | 4.2 ± 0.2 | 5.3 ± 0.5* | 5.4 ± 0.5* | 5.0 ± 0.5 | 5.2 ± 0.5* | 5.3 ± 0.6* | 5.5 ± 0.7* | |
Na+ (mmol/L) | ||||||||
Sham | 140 ± 1 | 140 ± 0 | 142 ± 1 | 140 ± 3 | 141 ± 1 | 139 ± 3 | 139 ± 1 | |
HAEMO | 139 ± 3 | 137 ± 2 | 137 ± 3 | 137 ± 2 | 137 ± 2 | 137 ± 2 | 136 ± 2 | |
LR | 141 ± 2 | 138 ± 4 | 137 ± 3 | 137 ± 3* | 136 ± 2* | 135 ± 3* | 135 ± 2* | |
TERLI | 140 ± 3 | 139 ± 3 | 137 ± 2 | 138 ± 3 | 138 ± 3 | 139 ± 3 | 139 ± 5 |