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Table 3 Unadjusted association between oxygen exposure over the first 24 h after ROSC (FIO2AUC) and baseline arrest and cardiopulmonary characteristics

From: Exposure to high concentrations of inspired oxygen does not worsen lung injury after cardiac arrest

Baseline predictor

B coefficient (95% CI)

P -value

Age

−0.035 (−0.069 to −0.001)

0.04

Male sex

0.438 (−0.658 to 1.535)

0.43

Out-of-hospital arrest

0.304 (−0.802 to 1.410)

0.59

Arrest rhythm VT/VF

1.306 (0.191 to 2.421)

0.02

Received TH

0.355 (−0.806 to 1.516)

0.55

PCAC

  

 1

Reference

Reference

 2

−0.246 (−1.823 to 1.332)

0.76

 3

2.346 (0.548 to 4.143)

0.01

 4

0.441 (−1.217 to 2.100)

0.60

First P:F ratio per 25

−0.262 (−0.354 to −0.170)

<0.001

Initial pulmonary compliance

0.010 (−0.035 to 0.054)

0.67

Initial SOFA-respiratory score

  

 0

Reference

Reference

 1

1.246 (−0.481 to 2.973)

0.16

 2

1.703 (−0.024 to 3.430)

0.05

 3

3.431 (1.815 to 5.047)

<0.001

 4

4.279 (2.540 to 6.018)

<0.001

Initial SOFA-cardiovascular score

  

 0

Reference

Reference

 1

−1.190 (−3.040 to 0.660)

0.21

 2

0.145 (−2.230 to 2.519)

0.90

 3

1.092 (−2.230 to 2.600)

0.15

 4

1.245 (−0.197 to 2.686)

0.09

Initial cardiovascular index

0.346 (0.061 to 0.630)

0.02

Time to first FiO2 wean

0.012 (−0.074 to 0.099)

0.78

Number of FiO2 changes in 24 h

−0.076 (−0.436 to 0.283)

0.68

  1. VT/VF, ventricular tachycardia/ventricular fibrillation; TH, therapeutic hypothermia; PCAC, Pittsburgh cardiac arrest category; P:F, ratio of partial pressure of arterial oxygen (PaO2) to fraction of inspired oxygen (FiO2); SOFA, sequential organ failure assessment.