Table 2 Intervention data
Variables | Citrate | Heparin | p |
|---|---|---|---|
(n = 54) | (n = 49) | ||
Delivered RRT dose, ml/kg/h | 29 (3) | 27 (5) | 0.005 |
Effective delivered RRT dose*, ml/kg/h | 28 (5) | 26 (4) | 0.15 |
Filter lifespan, h | 49 (29) | 28 (23) | 0.004 |
Mean heparin, IU/ml dose | 6,757 (5,455) | 10,567 (7,760) | 0.005 |
Laboratory follow-up data | |||
Total calcium, mmol/L, day 1 | 2.34 (0.20) | 2.31 (0.19) | 0.56 |
Ionized calcium, mmol/L, day 1 | 1.05 (0.10) | 1. 12 (0.09) | 0.04 |
pH, day 1 | 7.32 (0.10) | 7.31 (0.11) | 0.62 |
Bicarbonate, mmol/L, day 1 | 18 (4.6) | 19 (7.2) | 0.96 |
Na, mmol/L, day 1 | 136 (15) | 138 (7) | 0.42 |
Chloride, mmol/L, day 1 | 104 (15) | 108 (7) | 0.15 |
Potassium, mmol/L, day 1 | 6 (14) | 5.3 (5.6) | 0.61 |
Lactate, mmol/L, day 1 | 1.3 (0.9 to 2.9) | 1.3 (0.8 to 1.8) | 0.67 |
Total calcium, mmol/L, day 3 | 2.52 (0.19) | 2.41 (0.22) | 0.02 |
Ionized calcium, mmol/L, day 3 | 1.14 (0.10) | 1.20 (0.11) | 0.01 |
pH, day 3 | 7.40 (0,06) | 7.41 (0.06) | 0. 39 |
Bicarbonate, mmol/L, day 3 | 23.71 (1.81) | 25.17 (4.31) | 0.43 |
Na, mmol/L, day 3 | 138 (3.37) | 138 (4) | 0.71 |
Chloride, mmol/L, day 3 | 104 (3.4) | 107 (4) | 0.00 |
Potassium, mmol/L, day 3 | 4 (0.52) | 4.3 (0.6) | 0.03 |
Lactate, mmol/L, day 3 | 1.4 (0.9 to 2.2) | 1.1 (0.9 to 1.4) | 0.50 |
Side effects | 32 | 27 | 0.17 |
Bleeding | 0 | 4 (8) | |
HIT | 1 (2) | 2 (4) | |
Filter clotting | 3 (6) | 18 (37) | |
Metabolic disorders: | 14 | 3 | |
Metabolic alcalosis | 3 | 0 | |
Respiratory alkalosis | 0 | 1 | |
Metabolic acidosis | 3 | 1 | |
Severe hypocalcemia | 6 | 1 | |
Ca total/calcium ion ratio >2.5 | 1 | 0 | |
CRRT, days | 3 (2 to 6) | 3 (2 to 5) | 0.30 |
ICU, days | 7 (4 to 15) | 7 (4 to 12) | 0.79 |
Hospital, days | 22 (6 to 35) | 16 (9 to 30) | 0.45 |
Survival at 28 days | 43 (80) | 36 (74) | 0.46 |
Survival at 90 days | 40 (74) | 35 (73) | 0.90 |