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Figure 7 | Critical Care

Figure 7

From: β1-adrenoceptor stimulation promotes LPS-induced cardiomyocyte apoptosis through activating PKA and enhancing CaMKII and IκBα phosphorylation

Figure 7

Effect of atenolol pretreatment on myocardial apoptosis-associated molecules in endotoxemic mice. Animals received intraperitoneal injection of normal saline or atenolol (ATE, 10 mg/kg) 1 hour before normal saline or 20 mg/kg LPS administration. (A) Myocardial TNF-α content was determined by ELISA at 2 hours after LPS challenge (mean ± standard error of the mean (SEM); n = 10). (B-F) Myocardial p38 mitogen-activated protein kinase (MAPK) and c-jun NH2-terminal kinase (JNK) phosphorylation, Bcl-2 contents, Cyt c release and calmodulin-dependent protein kinase II (CaMKII) phosphorylation were determined using western blotting at 2 hours after lipolysaccharide (LPS) challenge (mean ± SEM; n = 5 to 6). * P <0.05 compared with the control group; # P <0.05 compared with the LPS group.

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Critical Care

ISSN: 1364-8535