Mean interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) levels in the cerebral microdialysate of 26 aneurysmal subarachnoid hemorrhage patients at given time points after neuromonitoring was started. Significant decrease of (A) CMD-IL-6 over neuromonitoring time. Panel (B) shows significantly higher levels of CMD-IL-6 in patients developing new infarcts on head computed tomography (CT) scan. Panel (C) shows a significant decrease of CMD-MMP-9 over neuromonitoring time. (D) Median CMD-IL-6 (interquartile range) levels within the first 12 hours of neuromonitoring in patients with cerebral perfusion pressure (CPP) below (n=9/26, 35%) and above (n=17/26, 65%) 70 mm Hg. CPP is averaged over CMD sampling time. *P <0.05, ***P <0.001. Values are presented as mean±standard error of the mean.