Table 4 Large studies of ECMO for H1N1-induced ARDS

Patients, n

123^$

69^£

68

49

36

15

14

13

Number of centers

33

4

15

14

3

1

12

1

Study design

Case control

Case control

Case control

Case series

Case series

Case series

Case series

Case series

Newcastle-Ottawa scale

9

8

8

7

–

–

–

–

Age, years

42 (32–53)

34 (28–46)

36 (27–45)

39 (32–46)

39 (28–53)

34 ± 4

54 (43–60)

31 (25–50)

BMI, kg/m²

30.5 ± 8.0

–

29 (23–36)

27 (24–35)

29 (25–36)

–

–

35 (31–42)

Pregnant or postpartum, n (%)

18 (15)

10 (17)

10 (16)

4 (8)

7 (19)

1(7)

1 (7)

3 (23)

SOFA

9.5 ± 4.0

9 (7–10)

7 (6–9)

11 (9–14)

–

16 (12–19)

–

Interval MV-ECMO, d

2 (1–5)

4 (2–7)

2 (1–5)

2 (1–5)

2 (0–5)

3.5 ± 0.8

5.0 (0.8–8.5)

1 (0–7)

Pre-ECMO parameters

pH

7.26 ± 0.12

–

7.20 (7.10–7.30)

7.30 (7.22–7.40)

7.22 (7.15–7.32)

–

–

7.30(7.30–7.40)

PaO₂/FiO₂, mmHg

59 (51–71)

55 (46–63)

56 (48–63)

63 (56–79)

50 (41–55)

62 ± 6

50 (40–55)

52 (38–60)

Plateau pressure, mmHg

32 (29–35)

–

36 (33–38)

33 (30–35)

32 (30–35)

–

30 (29–35)

37 (31–38)

Lung injury score

3.5 (3.0–4.0)

3.5 (3.5–3.7)

3.8 (3.5–4.0)

3.8 (3.3–3.8)

–

–

–

3.6 (3.3–4.0)

Any rescue therapy

91 (74)

–

–

–

35 (97)

–

4 (29)

–

Nitric oxide, %

72

19

32

15

89

–

7

–

Prone position, %

45

34

20

28

67

–

21

–

Duration of ECMO, days

11 (8–22)

9 (6–12)

10 (7–15)

10 (7–17)

20 (9–38)

9 ± 1

9 (4–11)

16 (9–30)

Mortality, n (%)

44 (36)

22 (28)

17 (25)

14 (29)

6 (17)

6 (40)

9 (64)

2 (15)