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Table 4 Large studies of ECMO for H1N1-induced ARDS

From: Extracorporeal gas exchange for acute respiratory failure in adult patients: a systematic review

  Pham [ 17 ] Noah [ 16 ] Davies [ 15 ] Patroniti [ 48 ] Schmidt [ 33 ] Michaels [ 46 ] Takeda [ 43 ] Holzgraefe [ 40 ]
Patients, n 123$ 69£ 68 49 36 15 14 13
Number of centers 33 4 15 14 3 1 12 1
Study design Case control Case control Case control Case series Case series Case series Case series Case series
Newcastle-Ottawa scale 9 8 8 7
Age, years 42 (32–53) 34 (28–46) 36 (27–45) 39 (32–46) 39 (28–53) 34 ± 4 54 (43–60) 31 (25–50)
BMI, kg/m2 30.5 ± 8.0 29 (23–36) 27 (24–35) 29 (25–36) 35 (31–42)
Pregnant or postpartum, n (%) 18 (15) 10 (17) 10 (16) 4 (8) 7 (19) 1(7) 1 (7) 3 (23)
SOFA 9.5 ± 4.0 9 (7–10)   7 (6–9) 11 (9–14) 16 (12–19)
Interval MV-ECMO, d 2 (1–5) 4 (2–7) 2 (1–5) 2 (1–5) 2 (0–5) 3.5 ± 0.8 5.0 (0.8–8.5) 1 (0–7)
Pre-ECMO parameters         
pH 7.26 ± 0.12 7.20 (7.10–7.30) 7.30 (7.22–7.40) 7.22 (7.15–7.32) 7.30(7.30–7.40)
PaO2/FiO2, mmHg 59 (51–71) 55 (46–63) 56 (48–63) 63 (56–79) 50 (41–55) 62 ± 6 50 (40–55) 52 (38–60)
Plateau pressure, mmHg 32 (29–35) 36 (33–38) 33 (30–35) 32 (30–35) 30 (29–35) 37 (31–38)
Lung injury score 3.5 (3.0–4.0) 3.5 (3.5–3.7) 3.8 (3.5–4.0) 3.8 (3.3–3.8) 3.6 (3.3–4.0)
Any rescue therapy 91 (74) 35 (97) 4 (29)
Nitric oxide, % 72 19 32 15 89 7
Prone position, % 45 34 20 28 67 21
Duration of ECMO, days 11 (8–22) 9 (6–12) 10 (7–15) 10 (7–17) 20 (9–38) 9 ± 1 9 (4–11) 16 (9–30)
Mortality, n (%) 44 (36) 22 (28) 17 (25) 14 (29) 6 (17) 6 (40) 9 (64) 2 (15)
  1. BMI: body mass index; SOFA: sequential organ failure assessment; MV: mechanicalventilation.
  2. Data are given as mean ± SD or median (interquartile range).
  3. $Winter 2009–2010: 73 patients, winter 2010–2011: 50 patients.
  4. £80 patients were transferred to Leicester for consideration to receive ECMO and 69 received thedevice.