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Table 2 Large, recent studies of ECMO for acute respiratory failure: Key pre-ECMO data and outcomes

From: Extracorporeal gas exchange for acute respiratory failure in adult patients: a systematic review

First author [ref] PaO 2 /FiO 2 pH Plateau pressure PEEP LIS Delay MV – ECMO, hours Rescue therapies, % Duration of ECMO, days Hemorrhage, % Intracerebral hemorrhage, % Mortality, n (%)
Peek, ECMO Arm, CESAR trial [18] 76 ± 29 7.1 ± 0.1 14 ± 9 3.5 ± 0.6 36 (17–104) 10 (5–23) 0 33 (37%)
Schmidt [50] 59 (48–75) 7.25 (7.15–7.35) 36 (31–43)* 13 (10–16) 57 (19–151) 30 7 (4–13) 1,017 (43%)
Brogan [26] 57 (45–71) 7.27 (7.18–7.36) 40 (35–48)* 13 (10–16) 52 (20–160) 23 ± 20 30 4 732 (50%)
Enger [51] 69 (65–74) 7.22 (7.22–7.25) 35 (34–36)*† 16 (16–17) 3.5 (3.4–3.5) 120 (96–168) 10 (9–11) 117 (41%)
Hemmila [27] 55 ± 16 7.31 ± 0.12 44 ± 11* 13 ± 5 96 ± 72 9 ± 8 3 123 (48%)
Schmid [32] 77 ± 47 7.2 ± 0.2 35 ± 6* 18 ± 6 3.4 ± 0.5 144 ± 240 12 ± 9 78 (44%)
Schmidt [33] 53(43–60) 7.22(7.15–7.32) 32 (30–35) 10 (8–12) 120 (24–264) 94 15 (8–30) 46 3 50 (36%)
Lindskov [31] 48 (37–60) 7.26 ± 0.15 37 (35–41) 9 (1–23) 9 36 (29%)
Roch [49] 60 (50–70) 7.1 ± 0.2 32 (29–35) 3.5 (3.3–3.7) 48 (24– 194) 85 9 (7–13) 29 2 48 (56%)
Rega [74] 56 ± 18 7.22 ± 0.18 44 ± 11* 13 ± 3 108 ± 178 7 ± 5 20 40 (57%)
Mols [28] 96 ± 51 7.30 (7.22–7.40) 3.2 ± 0.4 12 ± 7 7 2 28 (45%)
Muller [35] 64 (48–86) 7.20 (7.13–7.30) 36 (32–40)* 16 (13–20) 3.6 (3.3–3.8) 1.0 (1.0–4.8) 9 (5–13) 30 33 (55%)
Lewandowski [29] 7.32 ± 0.10 39 ± 7* 12 ± 3 3.4 ± 0.2 312 ± 216 23 ± 17 22 (45%)
Forrest [34] 57 (47–65) 7.20 (7.13–7.3) 16 (12–18) 3.7 (3.5–3.7) 48 (24–48) 34 10 (7–17) 37 3 5 (13%)
Frenckner [75] 47 (31–65) 41 (29–54)* 13 (0–20) 3.5 (3.0–4.0) 120 (24–672) 100 17 (2–57) 16 8 13 (34%)
Michaels [46] 52 ± 3 68 ± 9 7 ± 1 6 15 (40%)
Beiderlinden [30] 63 ± 28 7.1 ± 0.2 19 ± 3 3.8 ± 0.3 132 ± 168 10 (7–15) 15 (47%)
  1. LIS, lung injury score; MV, mechanical ventilation; PEEP, positive end-expiratory pressure.
  2. Data are given as mean ± SD or median (interquartile range). *Peak pressure; in the survivors.