Dynamic changes of microbial flora and therapeutic consequences in persistent peritonitis

Table 7 Univariate and multivariate analyses of risk factors for emergence of microorganisms among the 173 reoperations in 98 patients with persistent peritonitis

Variable	Univariate analysis						Multivariate analysis
	Missing data	Emerging organisms	No emerging organisms	Odds ratio	95% CI	P -value	Odds ratio	95% CI	P -value
	Missing data	(n = 115)	(n = 58)	Odds ratio	95% CI	P -value	Odds ratio	95% CI	P -value
Time to reoperation, days	0	6 ± 5	4 ± 3	1.19	1.07, 1.35	0.001	1.19	1.06, 1.36	0.004
Initial infection involving E. coli	0	52 (45)	19 (33)	1.69	0.88, 3.32	0.14	-	-	-
Initial infection involving Enterobacter spp.	0	9 (8)	9 (16)	0.46	0.17, 1.25	0.18	-	-	-
Initial infection involving Candida	0	45 (39)	36 (62)	0.39	0.20, 0.75	0.0059	0.40	0.20, 0.77	0.007
Use of third-generation cephalosporins	0	7 (6)	9 (16)	0.35	0.12, 1.00	0.054	-	-	-
Use of glycopeptides	0	27 (23)	22 (38)	0.50	0.25, 0.99	0.051	-	-	-
Use of fluoroquinolones	0	13 (11)	1 (2)	7.26	1.39, 133.67	0.036	-	-	-
Inadequate anti-infective therapy	0	12 (10)	12 (21)	0.44	0.18, 1.07	0.10	-	-	-

Results are expressed as mean ± SD or total number (%). Time to reoperation (P = 0.0001 in univariate analysis), but not duration of therapy (P >0.2 in univariate analysis) was included in the model of risk factors for emergence of microorganisms. The variable, duration of therapy, was forced into the model but did not change the results. C-index: 0.71 (95% CI: 0.62, 0.79); Hosmer-Lemeshow test P-value: 0.19.

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