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Table 7 Univariate and multivariate analyses of risk factors for emergence of microorganisms among the 173 reoperations in 98 patients with persistent peritonitis

From: Dynamic changes of microbial flora and therapeutic consequences in persistent peritonitis

Variable Univariate analysis Multivariate analysis
Missing data Emerging organisms No emerging organisms Odds ratio 95% CI P -value Odds ratio 95% CI P -value
(n = 115) (n = 58)
Time to reoperation, days 0 6 ± 5 4 ± 3 1.19 1.07, 1.35 0.001 1.19 1.06, 1.36 0.004
Initial infection involving E. coli 0 52 (45) 19 (33) 1.69 0.88, 3.32 0.14 - - -
Initial infection involving Enterobacter spp. 0 9 (8) 9 (16) 0.46 0.17, 1.25 0.18 - - -
Initial infection involving Candida 0 45 (39) 36 (62) 0.39 0.20, 0.75 0.0059 0.40 0.20, 0.77 0.007
Use of third-generation cephalosporins 0 7 (6) 9 (16) 0.35 0.12, 1.00 0.054 - - -
Use of glycopeptides 0 27 (23) 22 (38) 0.50 0.25, 0.99 0.051 - - -
Use of fluoroquinolones 0 13 (11) 1 (2) 7.26 1.39, 133.67 0.036 - - -
Inadequate anti-infective therapy 0 12 (10) 12 (21) 0.44 0.18, 1.07 0.10 - - -
  1. Results are expressed as mean ± SD or total number (%). Time to reoperation (P = 0.0001 in univariate analysis), but not duration of therapy (P >0.2 in univariate analysis) was included in the model of risk factors for emergence of microorganisms. The variable, duration of therapy, was forced into the model but did not change the results. C-index: 0.71 (95% CI: 0.62, 0.79); Hosmer-Lemeshow test P-value: 0.19.