Table 2 Metabolites which are significantly different than the heathy baseline (t0,LPS) in the experimental condition and either of the two time points in the clinical conditions
A | LPS | Sepsis | ||
|---|---|---|---|---|
Metabolite name | Super pathway | t6 | t0 | t24 |
2-hydroxybutyrate (AHB) | Amino acid | ▲ | = | ▲ |
mannose | Carbohydrate | ▲ | = | ▲ |
xylose | Carbohydrate | ▲ | = | ▽ |
hexanoylcarnitine (C6) | Lipid | ▲ | ▲ | ▲ |
bilirubin | Cofactors and vitamins | ▲▲ | ▲ | ▲▲ |
docosapentaenoate (DPA; 22:5n3) | Lipid | ▲▲ | = | ▲ |
palmitoleate (16:1n7) | Lipid | ▲▲ | ▲ | ▲ |
pregnen-diol disulfate | Lipid | ▲▲ | ▲ | ▲ |
citrulline | Amino acid | ▽ | ▽ | ▽ |
histidine | Amino acid | ▽ | = | ▽ |
serine | Amino acid | ▽ | = | ▽ |
threonine | Amino acid | ▽ | ▽ | = |
2-palmitoyl-GPC (16:0) | Lipid | ▽ | ▽ | ▽ |
uridine | Nucleotide | ▽ | = | ▽ |
gamma-glutamyltyrosine | Peptide | ▽ | = | ▽ |
catechol sulfate | Xenobiotics | ▽▽ | ▽ | = |
B | LPS | SIRS | ||
Metabolite name | Super pathway | t6 | t0 | t24 |
alpha-ketobutyrate | Amino acid | ▲ | = | ▽ |
N-acetylglycine | Amino acid | ▲ | = | ▽ |
xylose | Carbohydrate | ▲ | = | ▽ |
citrate | Energy | ▲ | ▲ | ▲ |
arachidonate (20:4n6) | Lipid | ▲ | ▲ | ▲ |
docosahexaenoate (DHA; 22:6n3) | Lipid | ▲ | ▲ | = |
eicosapentaenoate (EPA; 20:5n3) | Lipid | ▲ | = | ▲ |
octadecanedioate (C18) | Lipid | ▲ | = | ▽ |
bilirubin | Cofactors and vitamins | ▲▲ | ▲ | = |
3-hydroxybutyrate (BHBA) | Lipid | ▲▲ | = | ▽▽ |
docosapentaenoate (DPA; 22:5n3) | Lipid | ▲▲ | ▲ | = |
hexadecanedioate (C16) | Lipid | ▲▲ | ▽▽ | ▽ |
palmitoleate (16:1n7) | Lipid | ▲▲ | ▲ | ▲ |
5-oxoproline | Amino acid | ▽ | ▽ | = |
proline | Amino acid | ▽ | = | ▲ |
serine | Amino acid | ▽ | ▲ | = |
1-linoleoyl-GPC (18:2) | Lipid | ▽ | ▲ | ▲ |
1-oleoyl-GPC (18:1) | Lipid | ▽ | = | ▲ |