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Table 6 Baseline participant characteristics and hospital course of community-acquired severe sepsis events (identified by manual chart review) and severe sepsis events identified by Angus and colleagues’ discharge diagnoses

From: Discharge diagnoses versus medical record review in the identification of community-acquired sepsis

Characteristic Community-acquired severe sepsis (column %) ( n = 122) Angus-severe sepsis (column %) ( n = 89) Discordances favoring community-acquired severe sepsis (column %) ( n = 70) Discordances favoring Angus-severe sepsis (column %) ( n = 37) Pvalue Community-acquired versus Angus-severe sepsis discordancesa
Age (mean ± SD) 70.3 (8.9) 72.1 (8.6) 69.3 (8.9) 72.9 (8.4) 0.049
Sex      
 Male 65.9 65.2 62.9 64.9 0.84
 Female 34.1 34.8 37.1 35.1
Race      
 White 65.6 68.5 70.0 18.9 0.21
 B lack 34.4 31.5 30.0 81.1
Income      
  < $20,000 23.8 29.2 20.0 29.7 0.43
 $20,000 to 34,000 36.9 36.0 38.6 37.8
 $35,000 to 74,000 21.3 20.2 18.6 13.5
  ≥ $75,000 10.7 5.6 14.3 5.4
 Unknown 7.4 9.0 8.6 13.5
Education      
 Less than high school 23.8 22.5 22.9 18.9 0.91
 High school graduate 27.1 28.9 31.4 37.8
 Some college 30.3 32.6 21.4 18.9
 College or higher 18.9 16.9 24.3 24.3
Health behaviors      
 Tobacco use      
  Never 31.4 28.4 37.1 35.1 0.98
  Past 53.7 55.7 50.0 51.4
  Current 14.9 15.9 12.9 13.5
 Alcohol use      
  None 65.3 71.9 63.8 78.4 0.29
  Moderate 30.6 24.7 31.9 18.9
  Heavy 4.1 3.4 4.4 2.7
Chronic medical conditions      
 Atrial fibrillation 16.7 18.4 17.1 21.6 0.58
 Cancer 18.1 25.8 11.3 24.0 0.16
 Chronic kidney disease 32.0 34.8 27.1 29.7 0.78
 Chronic lung disease 12.3 13.5 12.9 16.2 0.64
 Coronary artery disease 33.6 37.5 38.2 51.4 0.20
 Deep vein thrombosis 14.9 13.6 13.0 8.3 0.46
 Diabetes 34.4 42.1 32.9 50.0 0.09
 Dyslipidemia 61.8 74.7 61.8 72.7 0.28
 Hypertension 68.9 75.3 68.6 83.8 0.08
 Myocardial infarction 21.7 22.7 26.1 32.4 0.49
 Obesity (abnormal BMI or WC) 63.1 67.4 58.6 62.9 0.52
 Peripheral artery disease 4.1 7.9 1.43 8.11 0.09
 Stroke 20.7 20.2 18.8 16.2 0.74
Infection type      
 Lung 50.0 47.2 51.4 46.0 0.88
 Kidney 18.9 20.2 18.6 21.6  
 Abdominal 15.6 14.6 17.1 16.2  
 Skin 5.7 7.9 5.7 10.8  
 Other 9.8 10.1 7.1 5.4  
28-hour SOFA score 2 (1 to 3) 3 (2 to 4) 2 (1 to 3) 3 (1 to 4) 0.01
Median (IQR) MEDS score 10.5 (6 to 13) 11 (8 to 14) 9 (6 to 11) 9 (8 to 14) 0.25
Admission to ICU 16.4 24.7 7.1 18.9 0.07
Hospital mortality 11.5 22.5 4.3 24.3 0.002
  1. BMI, body mass index; IQR, interquartile range; MEDS, Mortality in Emergency Department Sepsis; SD, standard deviation; SOFA, Sequential Organ Failure Assessment; WC, waist circumference. aThe prevalence of each subject characteristic was evaluated by comparing the discordant pairs for each sepsis definition.