Table 6 Baseline participant characteristics and hospital course of community-acquired severe sepsis events (identified by manual chart review) and severe sepsis events identified by Angus and colleagues’ discharge diagnoses
From: Discharge diagnoses versus medical record review in the identification of community-acquired sepsis
Characteristic | Community-acquired severe sepsis (column %) ( n = 122) | Angus-severe sepsis (column %) ( n = 89) | Discordances favoring community-acquired severe sepsis (column %) ( n = 70) | Discordances favoring Angus-severe sepsis (column %) ( n = 37) | Pvalue Community-acquired versus Angus-severe sepsis discordancesa |
|---|---|---|---|---|---|
Age (mean ± SD) | 70.3 (8.9) | 72.1 (8.6) | 69.3 (8.9) | 72.9 (8.4) | 0.049 |
Sex | |||||
Male | 65.9 | 65.2 | 62.9 | 64.9 | 0.84 |
Female | 34.1 | 34.8 | 37.1 | 35.1 | |
Race | |||||
White | 65.6 | 68.5 | 70.0 | 18.9 | 0.21 |
B lack | 34.4 | 31.5 | 30.0 | 81.1 | |
Income | |||||
< $20,000 | 23.8 | 29.2 | 20.0 | 29.7 | 0.43 |
$20,000 to 34,000 | 36.9 | 36.0 | 38.6 | 37.8 | |
$35,000 to 74,000 | 21.3 | 20.2 | 18.6 | 13.5 | |
≥ $75,000 | 10.7 | 5.6 | 14.3 | 5.4 | |
Unknown | 7.4 | 9.0 | 8.6 | 13.5 | |
Education | |||||
Less than high school | 23.8 | 22.5 | 22.9 | 18.9 | 0.91 |
High school graduate | 27.1 | 28.9 | 31.4 | 37.8 | |
Some college | 30.3 | 32.6 | 21.4 | 18.9 | |
College or higher | 18.9 | 16.9 | 24.3 | 24.3 | |
Health behaviors | |||||
Tobacco use | |||||
Never | 31.4 | 28.4 | 37.1 | 35.1 | 0.98 |
Past | 53.7 | 55.7 | 50.0 | 51.4 | |
Current | 14.9 | 15.9 | 12.9 | 13.5 | |
Alcohol use | |||||
None | 65.3 | 71.9 | 63.8 | 78.4 | 0.29 |
Moderate | 30.6 | 24.7 | 31.9 | 18.9 | |
Heavy | 4.1 | 3.4 | 4.4 | 2.7 | |
Chronic medical conditions | |||||
Atrial fibrillation | 16.7 | 18.4 | 17.1 | 21.6 | 0.58 |
Cancer | 18.1 | 25.8 | 11.3 | 24.0 | 0.16 |
Chronic kidney disease | 32.0 | 34.8 | 27.1 | 29.7 | 0.78 |
Chronic lung disease | 12.3 | 13.5 | 12.9 | 16.2 | 0.64 |
Coronary artery disease | 33.6 | 37.5 | 38.2 | 51.4 | 0.20 |
Deep vein thrombosis | 14.9 | 13.6 | 13.0 | 8.3 | 0.46 |
Diabetes | 34.4 | 42.1 | 32.9 | 50.0 | 0.09 |
Dyslipidemia | 61.8 | 74.7 | 61.8 | 72.7 | 0.28 |
Hypertension | 68.9 | 75.3 | 68.6 | 83.8 | 0.08 |
Myocardial infarction | 21.7 | 22.7 | 26.1 | 32.4 | 0.49 |
Obesity (abnormal BMI or WC) | 63.1 | 67.4 | 58.6 | 62.9 | 0.52 |
Peripheral artery disease | 4.1 | 7.9 | 1.43 | 8.11 | 0.09 |
Stroke | 20.7 | 20.2 | 18.8 | 16.2 | 0.74 |
Infection type | |||||
Lung | 50.0 | 47.2 | 51.4 | 46.0 | 0.88 |
Kidney | 18.9 | 20.2 | 18.6 | 21.6 | |
Abdominal | 15.6 | 14.6 | 17.1 | 16.2 | |
Skin | 5.7 | 7.9 | 5.7 | 10.8 | |
Other | 9.8 | 10.1 | 7.1 | 5.4 | |
28-hour SOFA score | 2 (1 to 3) | 3 (2 to 4) | 2 (1 to 3) | 3 (1 to 4) | 0.01 |
Median (IQR) MEDS score | 10.5 (6 to 13) | 11 (8 to 14) | 9 (6 to 11) | 9 (8 to 14) | 0.25 |
Admission to ICU | 16.4 | 24.7 | 7.1 | 18.9 | 0.07 |
Hospital mortality | 11.5 | 22.5 | 4.3 | 24.3 | 0.002 |