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Table 1 Main characteristics of subjects enrolled in the study

From: Platelet mitochondrial dysfunction in critically ill patients: comparison between sepsis and cardiogenic shock

  Healthy controls Sepsis Cardiogenic shock P value
n 16 16 16  
Sex (male/female) 7/9 7/9 9/7 0.716
Age (years) 61 ± 11 62 ± 16 66 ± 17 0.306
Diabetes 1 2 6 0.110
Obesity 1 4 5 0.248
Smoking history 3 3 3 1.000
SAPS II 42 ± 12 75 ± 17 <0.001
SOFA score 9 (6 to 11) 12 (11 to 14) <0.001
 Respiration 3 (2 to 4) 3 (2 to 4) 0.984
 Coagulation 1 (0 to 2) 0 (0 to 0) 0.007
 Liver 0 (0 to 1) 0 (0 to 1) 0.748
 Cardiovascular 4 (3 to 4) 4 (3 to 4) 0.746
 Central nervous system 0 (0 to 0) 4 (3 to 4) <0.001
 Renal 0 (0 to 1) 1 (1 to 2) 0.022
Platelet count (× 103/mm3) 229 (191 to 268) 140* (93 to 183) 180 (153 to 221) <0.001
Central (or mixed) venous oxygen saturation (%) 74 ± 9 62 ± 14 0.015
Blood lactate (mmol/l) 2 ± 2 10 ± 5 <0.001
Antibiotic(s) 16 6 <0.001
Sedative(s) intravenously 13 12 1.000
Catecholamine(s) 13 16 0.226
Mechanical ventilation 15 15 1.000
Renal replacement therapy 0 1 1.000
Intra-aortic balloon pump 0 2 0.484
Days from hospital to ICU admission 0 (0 to 1) 1 (0 to 8) 0.074
Hours from ICU admission to study enrolment 22 ± 13 9 ± 6 <0.001
Length of stay in ICU (days) 16 (6 to 24) 1 (1 to 2) <0.001
Deaths in ICU 5 10 0.156
  1. Data reported as number, mean ± standard deviation or median (interquartile range). Patients with sepsis or cardiogenic shock entered the study within 48 hours from admission to intensive care (ICU). Obesity was defined as body mass index ≥30 kg/m2. Smoking history was not known for two patients with sepsis and two patients with cardiogenic shock. Simplified Acute Physiology Score (SAPS) II and Sequential Organ Failure Assessment (SOFA) scores refer to the first day in the ICU. Central (n = 16) or mixed (n = 12) venous oxymetry (four missing values) and blood lactate levels (one missing value) are the worst values recorded from ICU admission to study enrolment. Use of artificial organ support refers to this same period of time. P values refer to Student’s t test or the Wilcoxon rank-sum test, one-way analysis of variance (ANOVA) or one-way ANOVA on ranks (*P <0.05 vs. healthy controls on post hoc all-pairwise multiple comparisons (Tukey or Dunn’s test)), chi-square test or Fisher’s exact test. In the case of two row × three column contingency tables, the Freeman–Halton extension of Fisher’s exact test was used as appropriate.