Propofol increases morbidity and mortality in a rat model of sepsis

Table 1 Serum liver and kidney marker profile at 24 and 12 hours

	AP [U/l]	ALT [U/l]	AST [U/l]	Bilirubin [mg/dl]	BUN [mg/dl]	Creatinine [mg/dl]
24-hour animals (sham and CLP)
isoflurane-sham	126(± 20)	33.8(± 7.6)	93(± 33)	0.109(± 0.027)	38.8(± 14.8)	0.33(± 0.13)
propofol-sham	367(± 161)***	35.6(± 6.1)	78(± 17)	0.176(± 0.055)*	59.4(±12.0)	0.72(± 0.32)
Isoflurane +CLP	253(± 117)*	68.5(± 38.7)*	210(± 177)	0.208(± 0.089)**	71.4(± 21.2)*	0.80(± 0.28)*
Sevoflurane + CLP	232(± 53)**	59.3(± 24.7)*	172(± 107)	0.186(± 0.073)*	73.1(± 33.0)**	0.88(± 0.52)**
Desflurane + CLP	262(± 60)***	42.1(± 16.1)	107(± 55)	0.151(± 0.024)	66.7(± 17.0)*	0.86(± 0.38)*
12-hour CLP animals
Isoflurane + CLP	187(± 46)	73.6(± 34.3)	222(± 136)	0.164(± 0.051)	58.6(± 12.7)	0.53(± 0.19)
propofol + CLP	264(± 185)^##	67.3(± 42.2)	168(± 109)	0.255(± 0.104)^#	43.3(± 22.4)	0.85(± 0.47)

*P <0.05, **P <0.01, ***P <0.001 versus sham-isoflurane; ^# P <0.05, ^## P <0.001 versus isoflurane + CLP 12 hour. ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CLP, cecal ligation and puncture.

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