Table 1 Selected studies evaluating mortality after ICU delirium
From: Contradictory findings on one-year mortality following ICU delirium
| Â | Significant association between delirium and mortality | No association | |||||
|---|---|---|---|---|---|---|---|
| Â | Ely: | Kiely: | Pisani: | Van Rompaey: | Shehabi: | Abelha: | Wolters: |
| Â | JAMA | JAGS | AJRCCM | J Clin Nutr | Crit Care Med | Crit Care | Crit Care |
Year | 2004 | 2009 | 2009 | 2009 | 2010 | 2013 | 2014 |
Location | USA | USA | USA | Netherlands | 5 countries | Portugal | Netherlands |
Study population | 224 ventilated MICU and CCU patients | 412 ICU survivors with delirium at discharge | 304 MICU patients | 105 non-intubated ICU patients | 354 ventilated ICU patients | 562 SICU patients with non-emergency surgery | 1,101 ICU patients |
Patient characteristics at admission | |||||||
Age (mean (sd)) | Del = 56 (17) | 84 (7) | 75 (9) | 62 | 62 (15) | Median (IQR) | 60 (17) |
No del = 54 (17) | Del = 65 (54-74) | ||||||
No del = 64 (53-73) | |||||||
Severity of illness (mean (sd)) | APACHE II | NR | APACHE II minus CNS component | APACHE II | APACHE II | Median (IQR) | APACHE IV |
Del = 26(8) | Del = 26(8) | 19 (7) | APACHE II | 61 (29) | |||
No del = 23(10) | 22 (6) | No del = 23(10) | Del = 9 (7-12) | ||||
No del = 8 (5-10) | |||||||
ICU mortality | 13% | NR | 16% | 7% | NR | 1% | 13% |
ICU LOS (median (IQR)) | NR | NR | 5 | Del = 13.4 | Del = 16 (7 - 23) | Del = <1 (<1–3) | Del = 8 (5 – 15) |
No del = 2.5 | No del = 4 (3 - 6) | No del = <1 (<1- <1) | No del = 3 (2-5) | ||||
Delirium measure | Binary; time-dependent | Persistence; time-varying | Days; time-varying | Binary | 0,1,2, ≥3 days | Binary | Binary |
Mortality assessment | |||||||
Time (months) | 6 | 12 | 12 | 3 and 6 | 1 | 6 | 12 |
Mortality in ICU survivors | NR | 39% | 41% | 11% (3 mo) | NR | 13% | 18% |
12% (6 mo) | |||||||
Model | Cox survival | Discrete time survival | Cox survival | Logistic | Cox survival | Logistic | Cox survival |
Results (95% CI) | HR = 3.2 | HR = 2.9 | HR = 1.1 | OR 3 and 6 mo: | HR 1,2, ≥3 versus | OR = 2.6 | HR = 1.26 |
(1.4-7.7) | (1.9-4.4) | (1.02-1.18) | 4.3 (1.3-14.7) | 0Â days: | (1.4-4.8) | (0.93-1.71) | |
3.8 (1.1-13.1) | 1.7 (1.3-2.3) | ||||||
2.7 (1.6-4.6) | |||||||
3.7 (1.9-7.2) | |||||||