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Table 3 Main differences among patients with putative or proven invasive aspergillosis, with regard to presence of immunosuppression a

From: Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes

  Immunosuppression ( n= 208) No immunosuppression ( n= 89) P -value
Age, yr 61 ± 15 63 ± 15 0.15
Male, n (%) 127 (61) 53 (60) 0.92
BMI, kg/m2 23 (20 to 27) 24 (21 to 28) 0.77
Underlying conditions, n (%)   
 COPD 67 (32) 35 (39) 0.23
 Chronic heart failure 14 (7) 13 (15) 0.06
 Diabetes 28 (14) 24 (27) 0.02
 Liver disease 16 (8) 11 (12) 0.19
 Chronic hemodialysis 6 (3) 5 (6) 0.25
 Smoking 24 (12) 19 (21) 0.03
 Alcohol abuse 12 (6) 15 (17) 0.002
Diagnostic category, n (%)   
 Medical admission 170 (82) 69 (78) 0.08
 Cardiovascular 49 (24) 29 (33) 0.1
 Respiratory 112 (54) 33 (37) 0.008
 Neurological 4 (2) 2 (2) 0.85
 Intoxication 1 (1) 0 0.51
 Gastrointestinal 11 (5) 8 (9) 0.23
 Endocrine 13 (6) 5 (6) 0.83
 Post-operative 18 (9) 4 (4) 0.21
 Trauma 0 5 (6) 0.006
 Others 2 (1) 1 (1) 0.89
Severity scores and main diagnoses   
 APACHE II score on admission 25 (17 to 30) 23 (17 to 28) 0.29
 Sepsis on ICU admission 103 (50) 38 (42) 0.07
 ARDS on ICU admission 33 (16) 22 (25) 0.07
 Septic shock, n (%) 28 (13) 16 (18) 0.31
 Traumatic brain injury, n (%) 1 (1) 0 0.51
 Pneumonia, n (%) 27 (13) 17 (19) 0.17
 Other brain injuries, n (%) 3 (1) 0 0.25
 Acute heart failure/CABG, n (%) 1 (1) 8 (9) <0.001
 Pancreatitis, n (%) 2 (1) 0 0.35
 Prophylactic antifungals, n (%) 24 (12) 3 (3) 0.03
 Antifungal therapy, n (%) 159 (76) 66 (74) 0.67
 Time from diagnosis to therapy, days 1 (0 to 3) 1 (0 to 4) 0.34
 Duration of therapy, daysb 11 (6 to 25) 14 (5 to 28) 0.83
 ICU stay before first positive culture, days 4 (2 to 11) 4 (2 to 10) 0.76
 SOFA II score at diagnosis 10 (6 to 13) 9 (6 to 12) 0.15
Organ support at time of diagnosis, n (%)   
 Vasopressor therapy 139 (67) 62 (70) 0.63
 RRT 67 (32) 42 (47) 0.01
 Mechanical ventilation 188 (90) 81 (91) 0.87
Organ support during ICU stay, n (%)   
 Vasopressor therapy 173 (83) 73 (82) 0.81
 RRT 83 (40) 45 (51) 0.09
 Mechanical ventilation 190 (91) 83 (93) 0.58
 12-week mortality 151 (73) 59 (66) 0.27
  1. aARDS, Acute respiratory distress syndrome; APACHE, Acute Physiology and Chronic Health Evaluation; BMI, Body mass index; CABG, Coronary artery bypass graft; COPD, Chronic obstructive pulmonary disease; ICU, Intensive care unit; RRT, Renal replacement therapy; SOFA, Sequential Organ Failure Assessment. bCalculated among those patients receiving therapy.