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Figure 2 | Critical Care

Figure 2

From: Effects of glucose-dependent insulinotropic polypeptide on gastric emptying, glycaemia and insulinaemia during critical illness: a prospective, double blind, randomised, crossover study

Figure 2

Effects of glucose-dependent insulinotropic polypeptide. Effects of glucose-dependent insulinotropic polypeptide (GIP; 4 pmol/kg/minute) on: (A) glycaemia (AUC–60 to 300: GIP, 2,843 (2,468 to 3,639) vs. control, 2,819 (2,578 to 3,788) mmol/l.300 minutes; P = 0.86); (B) glucose absorption (serum 3-O-methylglucose (3-OMG)) (AUC0 to 300: 50.6 (22.3 to 74.2) vs. 64.3 (9.9 to 96.3) mmol/l.300 minutes; P = 0.62); (C) insulin concentrations (AUC–60 to 300: 3,945 (2,280 to 6,731) vs. 3,479 (2,499 to 5,658) mU/l.300 minutes; P = 0.76); (D) GIP concentrations (*P <0.001; Bonferroni–Holm correction for all time points); (E) glucagon concentrations (incremental AUC–60 to 300: 4,217 (1,891 to 7,715) vs. 1,232 (293 to 4,545) pg/ml.300 minutes; P = 0.04). Data are median (25th to 75th percentile), analysed using Wilcoxon signed-rank test; n = 20. AUC, area under the concentration curve.

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ISSN: 1364-8535