Serum miR-122 correlates with short-term mortality in sepsis patients

Table 3 The association between miR-122 levels and 28-day mortality in sepsis patients

	All patients (n = 232)	RICU (n = 67)	SICU (n = 121)	EICU (n = 44)
Odds ratios of miR-122 (95% CI)
Unadjusted^a	0.775 (0.703, 0.853)	0.776 (0.664, 0.908)	0.77 (0.662, 0.894)	0.764 (0.610, 0.956)
	P < 0.001	P = 0.001	P = 0.001	P = 0.019
Adjusted^b	0.789 (0.713, 0.872)	0.777 (0.663, 0.911)	0.763 (0.655, 0.888)	0.650 (0.474, 0.891)
	P < 0.001	P = 0.002	P < 0.001	P = 0.007
Adjusted^b +	0.772 (0.690, 0.863)	0.781(0.665, 0.918)	0.791(0.677,0.925)	0.631 (0.448, 0.890)
SOFA score	P < 0.001	P = 0.003	P = 0.003	P = 0.009
Adjusted^b +	0.815 (0.734, 0.905)	0.709 (0.578, 0.870)	0.753 (0.639, 0.887)	0.622 (0.431, 0.897)
APACHE II score	P < 0.001	P = 0.001	P = 0.001	P = 0.011
Adjusted^b +	0.812 (0.724, 0.911)	0.868 (0.647, 0.967)	0.721 (0.599, 0.867)	0.376 (0.133, 0.865)
ARDS	P < 0.001	P = 0.023	P = 0.001	P = 0.034
The predictive value of miR-122
AUC (95% CI)	0.732 (0.665, 0.799)	0.763 (0.65,0.877)	0.706 (0.611,0.802)	0.770 (0.574, 0.966)
P-value	< 0.001	< 0.001	< 0.001	0.009
Sensitivity	79.5%	75.9%	79.4%	80%
Specificity	63.5%	70.3%	60.7%	81.8%

^aUnadjusted by any value. ^bAdjusted by age and gender. APACHE, Acute Physiology and Chronic Health Evaluation; ARDS, acute respiratory distress syndrome; AUC, are under the curve; EICU, Emergency Intensive Care Unit; RICU, Respiratory Intensive Care Unit; SICU, Surgery’s Intensive Care Unit; SOFA, Sequential Organ Failure Assessment.

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