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Table 1 Quality assessment of the included studies

From: Comparison of the effects of albumin and crystalloid on mortality in adult patients with severe sepsis and septic shock: a meta-analysis of randomized clinical trials

Authors Sequences generation Allocation concealment Blinding of participants and researchers Blinding of outcome assessment Incomplete outcome data Selective reporting Other bias Overall risk of bias
Rackow et al. [13] Unclear High High High Low Unclear Low High
Metildi et al. [15] Low High High High Low Unclear Low High
The SAFE study investigators [6] Low Low Low Low Low Unclear Low Unclear
The CRISTAL study investigators [14] Low Low High Low Low Unclear Low High
The ALBIOS study investigators [9] Low Low High High Low Low Low High
  1. Sequence generation: Rackow et al. [13] used predetermined randomization schedule. Metildi et al. [15] used random numbers. SAFE [6] used a central minimization algorithm. CRISTAL [14] and ALBIOS [9] used computer-generated sequences. Allocation concealment: no detailed allocation concealment was reported by Metildi et al. [15]. Rackow et al. [13] used a predetermined randomization schedule. SAFE [6] used a central minimization algorithm. CRISTAL [14] used sealed envelopes. ALBIOS [9] used a blinded assignment sequence. Blinding: blinding was not reported in Rackow et al. [13], Metildi et al. [15] and the ALBIOS [9] trial. Blinding was performed in the SAFE [6] trial. Data collection members but not researchers were blinded in the CRISTAL [14] trial. Incomplete outcome data: all trials described the follow-up. Selective reporting: the study protocol of ALBIOS [9] was obtained. Other bias: no evidence of other sources of bias.