Table 2 Pharmacokinetic analyses of individual markers a
| Â | Sinistrin | PAH | ( S )-pindolol | ( R )-pindolol | Fluconazole |
|---|---|---|---|---|---|
| Â | ( n =15) | ( n =19) | ( n =14) | ( n =14) | ( n =18) |
AUC0-∞, mcg/ml/min, mean (95% CI) | 16,513 (12,247 to 20,778) | 426 (366 to 487) | 8.70 (3.07 to 14.3) | 11.2 (1.42 to 21.0) | 3,804 (3,073 to 4,535) |
CL, ml/min, mean (95% CI) | 180 (141 to 219) | 1,139 (943 to 1,335) | 654 (465 to 842) | 639 (393 to 884) | 30.5 (24.4 to 36.6) |
Ae, mg, mean (95% CI) | – | 230 (211 to 249) | 0.80 (0.36 to 1.24) | 0.77 (0.39 to 1.15) | 35.9 (27.4 to 44.3) |
CLR, ml/min, mean (95% CI) | – | 594 (484 to 704) | 122 (77 to 167) | 98 (68 to 129) | 12.3 (7.61 to 16.9) |
CLNR, ml/min, mean (95% CI) | – | 545 (439 to 652) | 532 (369 to 695) | 541 (310 to 772) | 18.2 (15.5 to 21.0) |
CLNR, mean (95% CI) | – | 47.8 (43.5 to 52.0) | 80.9 (75.8 to 86.0) | 81.5 (76.3 to 86.8) | 64.1 (55.7 to 72.6) |
CLCR, ml/min, mean (95% CI) | 156 (125 to 188) | 164 (135 to 193) | 166 (127 to 204) | 166 (127 to 204) | 171 (140 to 203) |