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Table 2 Pharmacokinetic analyses of individual markers a

From: Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds

  Sinistrin PAH ( S )-pindolol ( R )-pindolol Fluconazole
  ( n =15) ( n =19) ( n =14) ( n =14) ( n =18)
AUC0-∞, mcg/ml/min, mean (95% CI) 16,513 (12,247 to 20,778) 426 (366 to 487) 8.70 (3.07 to 14.3) 11.2 (1.42 to 21.0) 3,804 (3,073 to 4,535)
CL, ml/min, mean (95% CI) 180 (141 to 219) 1,139 (943 to 1,335) 654 (465 to 842) 639 (393 to 884) 30.5 (24.4 to 36.6)
Ae, mg, mean (95% CI) 230 (211 to 249) 0.80 (0.36 to 1.24) 0.77 (0.39 to 1.15) 35.9 (27.4 to 44.3)
CLR, ml/min, mean (95% CI) 594 (484 to 704) 122 (77 to 167) 98 (68 to 129) 12.3 (7.61 to 16.9)
CLNR, ml/min, mean (95% CI) 545 (439 to 652) 532 (369 to 695) 541 (310 to 772) 18.2 (15.5 to 21.0)
CLNR, mean (95% CI) 47.8 (43.5 to 52.0) 80.9 (75.8 to 86.0) 81.5 (76.3 to 86.8) 64.1 (55.7 to 72.6)
CLCR, ml/min, mean (95% CI) 156 (125 to 188) 164 (135 to 193) 166 (127 to 204) 166 (127 to 204) 171 (140 to 203)
  1. aAe, Amount recovered in urine; AUC0-∞; Area under the concentration/time curve (extrapolated to infinity); CI, Confidence interval; CL, Clearance; CLCR, Creatinine clearance; CLNR, Non-renal clearance; CLR, Renal clearance; PAH, p-Aminohippuric acid.