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Table 2 Selected methodological characteristics of included studies

From: Does pulse pressure variation predict fluid responsiveness in critically ill patients? A systematic review and meta-analysis

Order Authors Year Vt (ml/kg) Body weight Spontaneous breathing Respiratory rate (times/minute) Cardiac arrhythmia Infusion fluid Infusion volume Infusion time (minutes) Indices Method for indices Cutoff value (%)
1 Michard and colleagues [23] 2000 8 to 12 NA No NA No 6% HES 500 ml 30 CI PAC 15
2 Kramer and colleagues [24] 2004 8 to 10 NA No NA No Blood 500 ml 10 to 15 CO PAC 12
3 Feissel and colleagues [25] 2005 8 to 10 NA No NA No 6% HES 7 ml/kg 30 CI Echo 15
4 Charron and colleagues [26] 2006 6 to 10 NA No 14 to 20 No 6% HES 100 ml 1 SV Echo 15
5 Monnet and colleagues [27] 2006 NA NA No 23 ± 5 No Saline 500 ml 10 Aortic blood flow Esophageal Doppler 15
6 Feissel and colleagues [28] 2007 8 to 10 NA No NA No 6% HES 8 ml/kg 30 CI Echo 15
7 Wyffels and colleagues [29] 2007 8 to 10 NA No NA No 6% HES 500 ml 20 CO PAC 15
8 Auler and colleagues [30] 2008 8 NA No NA No LR 20 ml/kg 20 CI PAC 15
9 Monge Garcia and colleagues [31] 2009 9 Ideal No 18 to 20 No 6% HES 500 ml 30 SV FloTrac 15
10 Vistisen and colleagues [32] 2009 8.1a Predicted NA 14 No 6% HES 500 ml 45 CI PAC 15
11 Loupec and colleagues [33] 2011 8 to 10 Predicted No NA No 6% HESb 500 ml 10 CO Echo 15
12 Biais and colleagues [34] 2012 8 to 10 Predicted No 16 ± 3c No Saline 500 ml 15 SV Echo 15
13 Cecconi and colleagues [35] 2012 8 Ideal No 14 No Colloid 250 ml 5 CO LiDCO plus 15
14 Fellahi and colleagues [36] 2012 NA NA NA 12 ± 2 No 6% HES 500 ml 15 CI PiCCO2 15
15 Khwannimit and colleagues [37] 2012 ≥ 8 NA No NA No 6% HES 500 ml 30 SV FloTrac 15
16 Monnet and colleagues [38] 2012 8.8d Predicted No NA No Saline 500 ml 20 CI PiCCO2 15
17 Monnet and colleagues [39] 2012 8.5e Predicted No NA No Saline 500 ml 30 CI PiCCO2 15
18 Yazigi and colleagues [40] 2012 8 NA No 12 No 6% HES 7 ml/kg 20 SV PAC 15
19 Fischer and colleagues [41] 2013 8.6 NA NA NAf No 6% HES 500 ml 15 CI PiCCO2 15
20 Fischer and colleagues [42] 2013 8.2 NA No NAc No 6% HES 500 ml 15 CI PiCCO2 15
21 Ishihara and colleagues [43] 2013 ≥ 8 Ideal No 12 to 15 No 10% dextran 250 ml 20 CI PiCCO 15
22 Monnet and colleagues [44] 2013 9 Predicted No NA No Saline 500 ml 30 CI PiCCO2 15
  1. CI, cardiac index; CO, cardiac output; Echo, echocardiography; HES, hydroxyethyl starch; LR, Ringer’s lactate; NA, not available; PAC, pulmonary artery catheter; SV, stroke volume; Vt, tidal volume. aMean Vt of 6.9 ml/kg actual body weight. bSome patients evaluated with passive leg raising test. cHeart rate/respiratory rate >3.6. dOnly mean Vt >8 ml/kg included. eMean Vt of 7.4 ml/kg for nonresponder. fHeart rate/respiratory rate = 5.7.