Table 4 Bootstrap parameter estimates of the final covariate model
Parameter | Vancomycin | ||||
|---|---|---|---|---|---|
Model mean | Model standard error % | Bootstrap | |||
Mean | 95% confidence interval | ||||
2.5% | 97.5% | ||||
Fixed effects | |||||
CL (L/h) | 3.7 | 19.5 | 3.7 | 3.1 | 4.4 |
CLCRRT (L/h) | 0.6 | 20.2 | 0.6 | 0.2 | 0.8 |
CLNOCRRT (L/h) | 1.0 | 8.0 | 0.9 | 0.6 | 1.2 |
Vc (L) | 31.8 | 10.7 | 31.6 | 25.5 | 37.9 |
Vp (L) | 57.1 | 13.5 | 68.8 | 29.9 | 152.1 |
Q (L/h) | 3.6 | 36.4 | 3.7 | 3.0 | 4.7 |
Random effects BSV, % CV | |||||
CL (L/h) | 16.4 | 42.0 | 20.4 | 0.4 | 33.9 |
Vc (L) | 47.0 | 36.2 | 45.5 | 31.1 | 63.7 |
Vp (L) | 101.0 | 72.8 | 95.5 | 34.7 | 183.1 |
Random error | |||||
RUV, % CV | 8.5 | 35.5 | 7.7 | 5.0 | 10.2 |