Fluid balance, intradialytic hypotension, and outcomes in critically ill patients undergoing renal replacement therapy: a cohort study

Table 2 Final multiple logistic regression model for mortality

Variable	Unadjusted OR	P value	Adjusted OR	P value
Variable	(95% CI)	P value	(95% CI)	P value
Mean daily fluid balance (per 1000 mL positive)	1.47 (1.30-1.66)	<0.001	1.36 (1.18-1.57)	<0.001
Intradialytic hypotension (per 10% increase in number of days)	1.27 (1.19-1.35)	<0.001	1.14 (1.06-1.23)	<0.001
Age (per 5-year increase)	1.07 (1.02-1.14)	0.01	1.15 (1.07-1.25)	<0.001
Male sex	0.95 (0.66-1.36)	0.78	1.04 (0.66-1.64)	0.85
Charlson comorbidity index	1.16 (1.07-1.26)	<0.001	1.28 (1.14-1.44)	<0.001
Primary renal diagnosis	0.44 (0.24-0.78)	0.005	0.82 (0.40-1.66)	0.58
Baseline creatinine (per 10 μmol/L increase)	0.98 (0.97-0.99)	<0.001	0.98 (0.97-0.996)	0.01
Abdominal aortic aneurysm repair	0.48 (0.22-1.07)	0.07	0.52 (0.20-1.36)	0.18
Maximum SOFA on days 1-7	1.22 (1.16-1.28)	<0.001	1.21 (1.13-1.29)	<0.001
Any vasopressors on days 1-7	3.07 (2.12-4.44)	<0.001	1.58 (0.96-2.62)	0.07
Initial RRT modality
CRRT vs. IHD	2.65 (1.79-3.91)	<0.001	0.59 (0.34-1.02)	0.06
sLED vs. IHD	1.50 (0.85-2.67)	0.16	0.69 (0.34-1.40)	0.30

The final model had 492 patients and 251 deaths; it did not demonstrate lack of goodness of fit (Hosmer-Lemeshow P = 0.85). CI, confidence interval; CRRT, continuous renal replacement therapy; IHD, intermittent hemodialysis; OR, odds ratio; RRT, renal replacement therapy; SLED, sustained low-efficiency dialysis; SOFA, sequential organ failure assessment score.

ISSN: 1364-8535