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Table 2 Clinical and demographic characteristics of the septic shock subclasses

From: Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock

Variable Group A Group B Group C
  (n = 54) (n = 73) (n = 53)
Age, yearsa 1.0 (0.1 - 3.2) 4.5 (1.8 - 8.0)c 2.1 (1.2 - 4.8)
Male sex, n (%) 37 (69) 38 (52) 34 (64)
Comorbid condition, n (%) 20 (37) 36 (49) 20 (38)
Blood counts at time of blood draw    
Total WBC count × 103 7.3 (2.4 - 13.6)d 15.9 (9.0 - 23.6) 15.0 (7.8 - 19.2)
% Neutrophils 60 (34 - 78)e 76 (70 - 85) 72 (61 - 81)
% Lymphocytes 33 (13 - 46)d 12 (6 - 22) 18 (9 - 30)
Monocytes 7 (3 - 10) 4 (2 - 8) 6 (3 - 8)
Platelet count × 103 112 (59 - 166) 126 (88 - 228) 183 (67 - 303)
Type of infection, n (%)    
Gram-positive bacteria 19 (36) 18 (25) 15 (28)
Gram-negative bacteria 9 (17) 16 (22) 11 (21)
Other organism 3 (6) 4 (5) 6 (11)
Negative cultures 22 (42) 35 (48) 21 (40)
Maximum number of organ failuresa 3 (3 - 4)d 2 (2 - 3) 2 (2 - 2)
PRISM III scorea 19 (12 - 31)d 12 (9 - 18) 15 (8 - 9)
PERSEVERE mortality probability, %b 18.7 (12.4, 25.0)d 10.8 (7.1, 14.5) 6.6 (3.2, 10.0)
Insulin, n (%) 1 (2) 5 (7) 2 (4)
Corticosteroids, n (%) 20 (37) 39 (53) 11 (18)f
Nonsurvivors, n (%) 16 (30)d 9 (12) 4 (8)
Lactate, mmol/La 4.7 (2.4 - 8.3)g 1.9 (1.2 - 3.5) 1.7 (0.9 - 2.8)
  1. aMedian (interquartile range); bmean (95% confidence interval); cP <0.05 compared to groups A and C; dP <0.05 compared to groups B and C; eP <0.05 compared to group B; fP <0.05 compared to groups A and B; gP <0.05 compared to groups B and C. Incomplete data: 28 group A subjects, 45 group B subjects, and 32 group C subjects had available lactate data. PRISM, pediatric risk of mortality; PERSEVERE, pediatric sepsis biomarker risk model.