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Table 2 Clinical and demographic characteristics of the septic shock subclasses

From: Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock

Variable

Group A

Group B

Group C

 

(n = 54)

(n = 73)

(n = 53)

Age, yearsa

1.0 (0.1 - 3.2)

4.5 (1.8 - 8.0)c

2.1 (1.2 - 4.8)

Male sex, n (%)

37 (69)

38 (52)

34 (64)

Comorbid condition, n (%)

20 (37)

36 (49)

20 (38)

Blood counts at time of blood draw

   

Total WBC count × 103

7.3 (2.4 - 13.6)d

15.9 (9.0 - 23.6)

15.0 (7.8 - 19.2)

% Neutrophils

60 (34 - 78)e

76 (70 - 85)

72 (61 - 81)

% Lymphocytes

33 (13 - 46)d

12 (6 - 22)

18 (9 - 30)

Monocytes

7 (3 - 10)

4 (2 - 8)

6 (3 - 8)

Platelet count × 103

112 (59 - 166)

126 (88 - 228)

183 (67 - 303)

Type of infection, n (%)

   

Gram-positive bacteria

19 (36)

18 (25)

15 (28)

Gram-negative bacteria

9 (17)

16 (22)

11 (21)

Other organism

3 (6)

4 (5)

6 (11)

Negative cultures

22 (42)

35 (48)

21 (40)

Maximum number of organ failuresa

3 (3 - 4)d

2 (2 - 3)

2 (2 - 2)

PRISM III scorea

19 (12 - 31)d

12 (9 - 18)

15 (8 - 9)

PERSEVERE mortality probability, %b

18.7 (12.4, 25.0)d

10.8 (7.1, 14.5)

6.6 (3.2, 10.0)

Insulin, n (%)

1 (2)

5 (7)

2 (4)

Corticosteroids, n (%)

20 (37)

39 (53)

11 (18)f

Nonsurvivors, n (%)

16 (30)d

9 (12)

4 (8)

Lactate, mmol/La

4.7 (2.4 - 8.3)g

1.9 (1.2 - 3.5)

1.7 (0.9 - 2.8)

  1. aMedian (interquartile range); bmean (95% confidence interval); cP <0.05 compared to groups A and C; dP <0.05 compared to groups B and C; eP <0.05 compared to group B; fP <0.05 compared to groups A and B; gP <0.05 compared to groups B and C. Incomplete data: 28 group A subjects, 45 group B subjects, and 32 group C subjects had available lactate data. PRISM, pediatric risk of mortality; PERSEVERE, pediatric sepsis biomarker risk model.