Table 1 Effect of atenolol on hemodynamic variables in ovine hyperdynamic sepsis

CO (L/min)

A

3.26 (2.80;3.79)

4.01(3.40;4.73)^†

4.71 (3.99;5.55)^†*

C

3.35 2.88;3.90)

4.13(3.50;4.86)^†

5.86 (4.97;6.90)^†*

HR (beats/min)

A

68 (59;79)

138 (116;163)^†

109 (92;129)^†*

C

68 (58;78)

133 (113;158)^†

152 (128;180)^†*

SV (mL/beat)

A

49.9 ± 4.3

30.4 ± 4.5†

45.0 ± 4.5^§*

C

51.3 ± 4.3

34.2 ± 4.5*

41.3 ± 4.5^§*

MAP (mmHg)

A

95.4 ± 4.9

96.0 ± 5.1

77.2 ± 4.8^§

C

93.7 ± 4.9

95.9 ± 5.1

83.2 ± 5.1^§

TPC (L/min/mmHg)

A

37.0 ± 4.2

44.2 ± 4.6§

69.2 ± 4.6^§

C

38.2 ± 4.4

45.0 ± 4.5†

77.4 ± 4.6)^§

RBF (mL/min)

A

198 (169;238)

268 (220;325)^†*

286 (236;348)^†*

C

212 (178;253)

330 (233;400)^†*

335 (277;407)^†*

RVC (mL/min/mmHg)

A

2.11 (1.78;2.50)

2.81(2.31;3.41)^†

3.75 (3.09;4.55)^†

C

2.32 (1.99;2.75)

3.48(2.88;4.21)^†

3.51 (2.93;4.2)^†