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Table 5 Univariate analysis of bad neurologic evolution (pediatric cerebral performance category (PCPC) >2) according to post-return of spontaneous circulation (ROSC) factors

From: Post return of spontaneous circulation factors associated with mortality in pediatric in-hospital cardiac arrest: a prospective multicenter multinational observational study

  Patients, % PCPC >2, % Odds ratio 95% CI P -value
Patients      
Mechanical ventilation      
No 4.7 16.7 1.000   
Yes 95.3 30.9 2.235 0.252 to 19.791 0.470
Vasoactive drugs      
No 42.1 18.4 1.000   
Yes 57.9 36 1.739 0.793 to 3.186 0.167
Adrenaline      
No 80.6 31 1.000   
Yes 19.4 28.6 0.889 0.358 to 2.207 0.800
Noradrenaline      
No 87.5 30.2 1.000   
Yes 12.5 33.3 1.158 0.405 to 3.313 0.785
Dopamine      
No 63.2 27.5 1.000   
Yes 36.8 35.8 1.475 0.714 to 3.049 0.294
Dobutamine      
No 74.3 24.3 1.000   
Yes 25.7 48.6 2.951 1.351 to 6.448 0.007
Milrinone      
No 82.6 32.8 1.000   
Yes 17.4 20 0.513 0.179 to 1.469 0.213
Vasoactive-inotropic score      
<14 48.1 43.2 1.000   
>14 51.9 35 0.707 0.282 to 1.772 0.459
Echocardiographic rhythm after ROSC      
Sinus rhythm 74 27.8 1.000   
Other rhythms 26 36.8 1.497 0.685 to 3.274 0.312
Recovery of spontaneous breathing      
Yes 65.3 25.5 1.000   
No 34.7 33.3 1.340 0.648 to 2.767 0.430
pH 1 h      
7.30 to 7.50 40.8 21.6 1.000   
<7.30 54.4 32.4 1.739 0.752 to 4.023 0.196
>7.50 4.8 33.3 1.818 0.293 to 11.265 0.521
PaO 2 1 h      
60 to 200 mmHg 45.2 33.3 1.000   
<60 mmHg 40.5 29.4 0.833 0.368 to 1.885 0.661
>200 mmHg 14.3 16.7 0.400 0.103 to 1.553 0.186
PaCO 2 1 h      
30 to 50 mmHg 62.1 23.4 1.000   
<30 mmHg 9.7 50 3.278 0.940 to 11.425 0.062
>50 mmHg 28.2 37.1 1.937 0.815 to 4.601 0.134
CO 3 H 1 h      
20 to 26 mEq/L 34.7 23.8 1.000   
<20 mEq/L 44.6 38.9 2.036 0.831 to 4.991 0.120
>26 mEq/L 20.7 20 0.800 0.239 to 2.683 0.718
BE      
+4 to -4 24.8 25 1.000   
<-4 61.1 33.3 1.500 0.557 to 4.041 0.423
> + 4 14.2 18.8 0.692 0.152 to 3.163 0.635
FiO 2 1 h      
<0.50 50.9 25.5 1.000   
0.50 to 0.79 25.9 32.1 1.125 0.324 to 3.909 0.853
≥0.80 23.1 44 1.125 0.409 to 3.097 0.820
PaO 2 /FiO 2 1 h      
>300 15.9 16.7 1.000   
200 to 300 12.4 14.3 3.049 0.083 to 11.149 0.092
<200 71.7 34.6 1.286 0.224 to 7.370 0.778
Lactic acid 1 h      
<2 mmol/L 21.3 6.2 1.000   
2 to 5 mmol/L 37.3 25 3.520 0.675 to 18.366 0.135
>5 mmol/L 41.3 41.9 9.263 1.883 to 45.560 0.006
pH 24 h      
7.30 to 7.50 80.6 26 1.000   
<7.30 12.9 43.8 2.214 0.749 to 6.545 0.151
>7.50 6.5 62.5 4.744 1.059 to 21.248 0.042
PaO 2 24 h      
60 to 200 mmHg 58.5 29.2 1.000   
< 60 mmHg 36.6 37.8 1.474 0.670 to 3.243 0.334
>200 mmHg 4.9 0 0   
PaCO 2 24 h      
30 to 50 mmHg 76.9 24.1 1.000   
<30 mmHg 5.6 50 3.150 0.589 to 16.859 0.180
>50 mmHg 17.6 52.6 3.500 1.248 to 9.819 0.017
CO 3 H 24 h      
20 to 26 mEq/L 43 26.9 1.000   
<20 mEq/L 15.7 26.3 0.969 0..295 to 3.189 0.959
>26 mEq/L 41.3 36 1.527 0.658 to 3.544 0.325
BE 24 h      
+4 to -4 50 19.6 1.000   
<-4 23.2 38.5 2.557 0.914 to 7.155 0.774
> + 4 26.8 46.7 3.580 1.351 to 9.482 0.010
FiO 2 24 h      
<0.50 21.4 28 1.000   
0.50 to 0.79 19.7 30.4 1.387 0.511 to 3.765 0.521
≥0.80 59 30.4 2.301 0.850 to 6.229 0.100
PaO 2 /FiO 2 24 h      
>300 21 13.6 1.000   
200 to 300 17.1 22.2 3.128 0.974 to 10.049 0.056
<200 61.9 40 1.312 0.284 to 6.067 0.728
Lactic acid 24 h      
<2 mmol/L 66.7 26.9 1.000   
2 to 5 mmol/L 20.5 31.2 1.234 0.364 to 4.187 0.736
>5 mmol/L 12.8 40 1.810 0.444 to 7.380 0.408
  1. Significant values marked in bold.