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Table 4 The integrated discrimination improvement index for prediction of mortality or dialysis

From: The clinical utility window for acute kidney injury biomarkers in the critically ill

 

IDI event

IDI non-event

IDI total

IS reference model

IS new model

IP reference model

IP new model

Plasma cystatin C

0.02

0.01

0.03

0.55

0.58

0.27

0.27

(0.0002 to 0.08)

(0.0001 to 0.047)

(0.0003 to 0.12)

(0.41 to 0.67)

(0.42 to 0.69)

(0.19 to 0.40)

(0.18 to 0.41)

Plasma NGAL

-0.003

0.01

0.01

0.55

0.56

0.27

0.26

(-0.05 to 0.04)

(-0.02 to 0.06)

(-0.04 to 0.09)

(0.41 to 0.67)

(0.39 to 0.68)

(0.19 to 0.40)

(0.18 to 0.40)

Urinary cystatin C/urinary creatinine

0.02

0.01

0.03

0.55

0.58

0.27

0.27

(-0.0003 to 0.09)

(-0.0002 to 0.06)

(-0.0005 to 0.15)

(0.42 to 0.68)

(0.42 to 0.69)

(0.19 to 0.40)

(0.19 to 0.42)

Urinary NGAL/urinary creatinine

0.06

0.04

0.11

0.55

0.62

0.27

0.24

(0.002 to 0.19)

(0.002 to 0.12)

(0.003 to 0.30)

(0.41 to 0.67)

(0.45 to 0.76)

(0.19 to 0.41)

(0.15 to 0.39)

Urinary AP/urinary creatinine

0.0002

0.0002 (-0.001 to

0.0004

0.55

0.56

0.27

0.28

(-0.002 to 0.005)

0.003)

(-0.003 to 0.008)

(0.40 to 0.67)

(0.39 to 0.67)

(0.19 to 0.39)

(0.20 to 0.42)

Urinary GGT/urinary creatinine

0.003

0.002

0.005

0.55

0.56

0.27

0.28

(-0.0006 to 0.04)

(-0.0004 to 0.02)

(-0.0009 to 0.06)

(0.41 to 0.68)

(0.42 to 0.69)

(0.19 to 0.41)

(0.21 to 0.42)

Urinary α-GST/urinary creatinine

0.006

0.004

0.009

0.55

0.57

0.27

0.28

(-0.0005 to 0.05)

(-0.0003 to 0.03)

(-0.0008 to 0.08)

(0.40 to 0.67)

(0.40 to 0.67)

(0.19 to 0.41)

(0.20 to 0.42)

Urinary α-GST/urinary creatinine

0.02

0.02

0.04

0.55

0.58

0.27

0.26

(0.0001 to 0.11)

(0.0001 to 0.07)

(0.0002 to 0.17)

(0.40 to 0.67)

(0.43 to 0.70)

(0.19 to 0.41)

(0.18 to 0.41)

Urinary albumin/urinary creatinine

0.03

0.02

0.06

0.55

0.60

0.27

0.25

(0.0006 to 0.12)

(0.0006 to 0.080)

(0.0009 to 0.19)

(0.42 to 0.68)

(0.44 to 0.71)

(0.19 to 0.40)

(0.18 to 0.38)

  1. Data expressed with 95% confidence interval. Reference model: acute physiological and chronic health evaluation-II score (without creatinine), and the presence of AKI24 both within 24 h of admission. New model: addition of maximal individual biomarker level within 24 h of admission to the reference model. IDI, integrated discrimination improvement. IDI event, IDI: improvement in risk prediction model for mortality or dialysis; IDI non-event, improvement in risk prediction model for no mortality or dialysis; IP, integrated specificity, that is, differences in average specificity of reference and new model; IS, integrated sensitivity, that is, differences in average sensitivity of reference and new model; NGAL, neutrophil gelatinase-associated lipocalin; AP, alkaline phopshatase; GGT, gamma-glutamyltranspeptidase; GST, glutathione-S-transferase.
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Critical Care

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