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Table 3 Predictors of hospital mortality a

From: Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study

 

Odds ratio

95% confidence interval

P value

Non-IAAT

3.872

2.770 to 5.413

<0.001

Chronic liver disease

1.942

1.319 to 2.860

0.001

Septic shock

1.846

1.335 to 2.553

<0.001

Pneumonia

1.766

1.237 to 2.522

0.002

Mechanical ventilation

1.669

1.172 to 2.376

0.005

APACHE II score (per 1 point)

1.076

1.047 to 1.105

<0.001

Surgery

0.701

0.560 to 0.879

0.002

Admitted from home

0.677

0.489 to 0.936

0.018

Urosepsis

0.675

0.469 to 0.972

0.034

  1. aIndependent variables included but not retained in the model at alpha ≤0.05: age, race, admission sources other than home (nursing home or transfer from another facility), comorbidities of congestive heart failure, chronic obstructive pulmonary disease, chronic kidney disease and human immune deficiency virus infection, Charlson comorbidity score, healthcare-associated infection risk factors (hemodialysis, immune suppression, prior hospitalization, prior antibiotics), mechanical ventilation, and infection source other than urine (lung, abdomen, line, central nervous system, skin). Variables pressors and severe sepsis were excluded because of collinearity with septic shock. APACHE, Acute Physiology and Chronic Health Evaluation; IAAT, initially appropriate antibiotic therapy. Area under the receiver operating characteristics curve = 0.777; Hosmer–Lemeshow P = 0.823.
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