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Table 1 Characteristics of responders (increase in stroke volume -15% after volume expansion) and non-responders to fluid challenge

From: Clinical relevance of pulse pressure variations for predicting fluid responsiveness in mechanically ventilated intensive care unit patients: the grey zone approach

  Responders Non-responders P value
(n = 267) (n = 289)
Age 58 ± 18 56 ± 17 0.40
Sex (women/men) 92/175 105/183 0.68
Height (cm) 169 ± 9 (n = 266) 169 ± 9 (n = 288) 0.72
Weight (kg) 72 ± 15 (n = 266) 75 ± 17 (n = 288) 0.053
IBW (kg) 63 ± 10 (n = 266) 63 ± 9 (n = 288) 0.76
SAPS II score 50 ± 20 (n = 147) 53 ± 20 (n = 188) 0.13
HR (beats/min) 91 ± 24 88 ± 25 0.066
MAP(mmHg) 73 ± 15 75 ± 16 0.12
RR (cycle/min) 19 ± 6 (n = 231) 19 ± 6 (n = 262) 0.55
V T /IBW (ml/kg) 7.4 ± 2.3 (n = 248) 7.6 ± 2.6 (n = 271) 0.57
V T /IBW <8 ml/kg (%) 109 (41%) 134 (46%) 0.24
PEEP 6 ± 5 (n = 249) 7 ± 5 (n = 271) 0.095
PPlat (cmH 2 O) 19.3 ± 5.5 (n = 205) 20.7 ± 5.8 (n = 225) 0.014
Driving pressure (cmH 2 O) 14 ± 5 (n = 192) 15 ± 5 (n = 211) 0.055
C st,rs (ml/cmH 2 O) 39.5 ± 14.3 (n = 192) 36.0 ± 13.5 (n = 211) 0.011
HR/RR 5.0 ± 1.5 (n = 231) 4.8 ± 1.6 (n = 262) 0.073
HR/RR ≤3.6 (n,%) 231 (17.8%) 262 (27.1%) 0.018
PaO 2 /FiO 2 ratio 185 ± 107 (n = 111) 182 ± 103 (n = 135) 0.85
Norepinephrine infusion -- -- --
Dosage (μ.kg -1 /min -1 ) 0.49 ± 0.67 (n = 158) 0.47 ± 0.63 (n = 172) 0.75
CVP (mmHg) 9 ± 5 11 ± 4 <0.001
Baseline SV 60 ± 21 74 ± 27 <0.001
PPV (%) 15 ± 9 9 ± 7 <0.001
  1. Data are presented as means ± standard deviation (SD); n = number of available data. CVP, central venous pressure; Cst,rs, static compliance of the respiratory system; driving pressure = plateau pressure - positive end-expiratory pressure; HR, heart rate; IBW, ideal body weight; MAP, mean arterial pressure; PaO2/FiO2 ratio, partial arterial oxygen pressure to inspiratory oxygen fraction ratio; PEEP, positive end-expiratory pressure; PPlat, plateau pressure; PPV: pulse pressure variation; RR, respiratory rate; SAPS II, Simplified Acute Physiology Score II; SV, stroke volume; VT, tidal volume.