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Table 2 Subgroup analyses of overall mortality a

From: The effect of goal-directed therapy on mortality in patients with sepsis - earlier is better: a meta-analysis of randomized controlled trials

Subgroups No. of studies No. of patients RR (95% CI) P-value I2(%)
All trials [6],[7],[16]-[26] 13 2,525 0.83 (0.71 to 0.96) 0.01 56
GDT timing
  Early [6],[7],[16],[22],[24]-[26] 7 2,062 0.77 (0.67 to 0.89) 0.0004 40
  Late or unclear [17]-[21],[23] 6 463 0.92 (0.69 to 1.24) 0.59 56
Risk of bias
  Low [6],[7],[19],[21],[22] 5 1,626 0.92 (0.75 to 1.13) 0.42 67
  Unclear [16]-[18],[20],[23]-[26] 8 899 0.74 (0.62 to 0.89) 0.002 31
Sample size
  100 [6],[7],[19],[22],[24]-[26] 7 2,192 0.82 (0.70 to 0.95) 0.01 59
  <100 [16]-[18],[20],[21],[23] 6 333 0.81 (0.56 to 1.17) 0.27 61
Setting
  ED [6],[7] 2 1,158 0.86 (0.52 to 1.44) 0.52 83
  ICU [16]-[26] 11 1,367 0.81 (0.69 to 0.96) 0.01 53
  1. aCI, Confidence interval; ED, Emergency department; GDT, Goal-directed therapy; ICU, Intensive care medicine; RR, Relative risk.