Figure 4
From: Early activation of pro-fibrotic WNT5A in sepsis-induced acute lung injury
Representative histological features of healthy and septic rat lungs and immunohistochemical staining for WNT5A and MMP7 activation in healthy and septic rat lungs. (A-D) Histological features: (A) normal lung (healthy) and (B) septic lung showing pulmonary infiltrates and perivascular edema; (C) normal lung (healthy) and (D) septic lung stained with Sirius-red assay for collagen content (× 200 magnification). (E- H) Red-pink color indicates positive staining for WNT5A (E, F) and metallopeptidase (MMP)7 (G, H) and blue/violet indicates nuclei counterstained with hematoxylin. WNT5A and MMP7 were observed in alveolar walls and septa (× 200 magnification).