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Figure 1 | Critical Care

Figure 1

From: Early activation of pro-fibrotic WNT5A in sepsis-induced acute lung injury

Figure 1

Activation of WNT5A/β-catenin pathway by E . coli lipopolysaccharide (LPS) in human BEAS-2B cells. (A) Changes in total WNT5A, cyclin D1, metallopeptidase (MMP)7 and vascular endothelial growth factor (VEGF) proteins (representative blots and mean densitometric values) following LPS stimulation for 18 h. Densitometry analysis of the active form (20 kDa) of MMP7 was normalized to the inactive form (30 kDa) and then normalized to β-actin. (B) Changes in non-phosphorylated (Ser33/37/Thr41) β-catenin protein bands were normalized to total β-catenin and β-actin. ***P <0.001 versus control-vehicle (C).

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