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Table 2 Mean parameter estimates and bootstrap mean (95% confidence interval) estimates for the final covariate model

From: The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study

Parameter Model Bootstrap
  Mean Mean 95% confidence interval
    2.5% 97.5%
Fixed effects
CL (L/h) 5.1 5.4 3.7 7.4
Vc (L) 18.7 18.2 13.0 21.0
Vp (L) 13.2 13.6 11.3 15.9
Q (L/h) 21.0 24.2 12.8 37.0
CLCRCL 1.89 1.85 0.99 2.65
Random effects BSV (% CV)
CL (L/h) 51.6 52.2 37.9 66.6
Vc (L) 45.8 48.4 32.1 69.9
Vp (L) 28.7 16.2 0.2 42.1
Random error
RUV (% CV) 13.7 13.3 10.1 17.6
RUV (SD, mg/L) 2.3 1.87 1.02 2.70
  1. CL, clearance; Vc, volume of distribution of the central compartment; Vp, volume of distribution of the peripheral compartment; Q, inter-compartmental clearance; CLCRCL, the fractional effect of CrCL on CL for patients not receiving RRT; BSV, between-subject variability; RUV, residual unexplained variability.