Alveolar pentraxin 3 as an early marker of microbiologically confirmed pneumonia: a threshold-finding prospective observational study

Table 2 Comparison of net reclassification index values for PTX3 levels in bronchoalveolar lavage fluid ^a

Comparisons with BAL fluid PTX3 ≥1 ng/ml	ΔSe	Δ(1-SP)	NRI
Plasma PTX3 ≥130 ng/ml	0.58	−0.21	0.38
Plasma PCT ≥0.5 ng/ml	0.25	0.19	0.44
Plasma CRP ≥0.5 mg/dl	−0.09	0.61	0.52
BAL fluid sTREM-1 ≥5 pg/ml	0.38	0.07	0.44
Plasma sTREM-1 ≥5 pg/ml	−0.04	0.60	0.56
CPIS ≥7	0.88	−0.34	0.53

^aBAL, Bronchoalveolar lavage fluid; CPIS, Clinical Pulmonary Infection Score; CRP, C-reactive protein; NRI, Net reclassification index; PCT, Procalcitonin; PTX3, Pentraxin 3; ΔSe, Change in sensitivity; Δ(1-SP), Change in 1-specificity; sTREM-1, Soluble triggering receptor expressed on myeloid cells 1.

ISSN: 1364-8535