Table 1 Summary of clinical studies evaluating the role of oxygen concentrations on outcome after cardiac arrest
Reference | Type | Patients (period)% of HO | OHCA | Definition HO | Evaluation | TH (% treated) | Cutoffa | Outcome | Main results |
|---|---|---|---|---|---|---|---|---|---|
During CPR | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Spindelboeck et al. [26] | R | 145 (8 years) 14% | 100% | >300 mm Hg | During CPR | NA | NR | In-hospital CPC | Higher rate of hospital admission in hyperoxemic patients |
After ROSC | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Kuisma et al. [27] | RCT | 28 (NA) 50% | 100% | 1 hour of ventilation at FiO2 100% | 24- and 48-hour | No (50%) | No | NSE and S100B | No difference in biomarkers of brain injury |
Post-CA care (ICU stay) | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Kilgannon et al. [28] | R/D | 6,326 (5 years) 18% | 43% | First ABG >300 mm Hg | 24-hour | NR ≈ 6% | No | In-hospital death | Increased hospital mortality in hyperoxemic patients |
Neurological function | |||||||||
Kilgannon et al. [29] | R/D | 4,459 (5 years) 18% | 45% | First ABG | 24-hour | NR ≈ 6% | No | In-hospital death | Increased hospital mortality for every 100 mm Hg increase in PaO2 |
Neurological function | |||||||||
Bellomo et al. [31] | R/D | 12,108 (10 years) 11% | 68% | Worst (A-a) ΔO2 > 300 mm Hg | 24-hour | NR ≈ 33% | No | In-hospital deathb | Hyperoxemia did not affect outcome when adjusted for several confounders. |
Janz et al. [32] | R | 170 (5 years) ≈ 25% | 80% | Highest PaO2 | 24-hour | Yes | No | In-hospital death | Increased hospital mortality for every 100 mm Hg increase in PaO2 |
In-hospital CPC | |||||||||
Ihle et al. [33] | R | 584 (5 years) ≈ 6% | 100% | Worst (A-a) ΔO2 > 300 mm Hg | 24-hour | NR | No | In-hospital death | Hyperoxemia did not affect outcome. |
Lee et al. [34] | R | 213 (4 years) <3% | 83% | Mean PaO2 value | 24-hour | Yes | No | In-hospital death | V-shaped association between the mean PaO2 and poor neurologic outcome at hospital discharge |
Vaahersalo et al. [35] | P | 409 (1 years) | 100% | Mean PaO2 value >300 mm Hg | 24-hour | Yes (71%) | No | 1-year CPC | PaO2 was not correlated to outcome |