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Figure 5 | Critical Care

Figure 5

From: Enhanced monocyte chemoattractant protein-1 production in aging mice exaggerates cardiac depression during endotoxemia

Figure 5

Neutralization of monocyte chemoattractant protein-1 (MCP-1) reduces myocardial injury. MCP-1-neutralizing antibody or keratinocyte chemoattractant (KC)-neutralizing antibody (NAb; 8 μg/mouse, iv) were administered 60 minutes after injection of lipopolysaccharide (LPS, 0.5 mg/kg, iv). Plasma levels of cardiac troponin-I (cTn-I) were analyzed by ELISA 6 h after LPS treatment. Neutralization of MCP-1, not KC, reduced cTn-I levels in plasma. Old mice displayed a greater reduction although cTn-I levels remain higher than those of adult mice receiving the same treatment. Data are expressed as mean ± standard error. *P <0.05 versus corresponding age group treated with LPS alone; #P <0.05 versus adult mice receiving the same treatment.

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Critical Care

ISSN: 1364-8535