Sodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis

Table 2 Sensitivity analysis according to various exclusion criteria for CSA-AKI

Criteria	Number of trials	Number of patients	SBIC group	Control group	RR (95% CI)	Pvalue	I²(%)
All included trials [2-6]	5	1,079	239/538	229/541	0.99 (0.78 to 1.24)	0.911	56.1
Full-text trials [3-6]	4	969	213/483	203/486	0.97 (0.72 to 1.29)	0.824	66.8
Large-scale trials (sample size >100) [2-4],[6]	4	987	225/494	209/493	1.02 (0.80 to 1.31)	0.867	61
Patients with pre-existing renal impairment or CKD [2],[4],[5]	3	552	123/273	110/279	1.08 (0.80 to 1.45)	0.631	45.9
Elective or urgent surgery [3-5]	3	542	113/268	110/274	0.88 (0.53 to 1.48)	0.637	77.9
Elective surgery [2],[6]	2	537	126/270	119/267	1.05 (0.87 to 1.26)	0.628	0

CI, confidence interval; CKD, chronic kidney disease; CSA-AKI, cardiac surgery-associated acute kidney injury; RR, relative risk; SBIC, sodium bicarbonate.

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