Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study

Wu, Xiaodan; Sun, Xiaoru; Chen, Chengshui; Bai, Chunxue; Wang, Xiangdong

doi:10.1186/s13054-014-0508-y

Critical Care

Table 4 Genes upregulated >30-fold in peripheral blood mononuclear cells ^a

From: Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study

Stable vs control		AE-1 vs control		AE-3 vs control		AE-10 vs control
Fold changes	Genes	Fold changes	Genes	Fold changes	Genes	Fold changes	Genes
31.7	REXO1L2P	30.3	HP	30.1	FOS	30.8	EMP2
33.0	DEFA1	30.5	LOC152573	30.6	BPIL1	31.0	SEPP1
33.3	DUB3	31.2	INHBA	31.0	ARG1	31.0	FOLR1
37.2	LOC402207	31.4	COL6A3	31.6	N/A	31.1	GPX3
37.3	DUB3	32.4	MPO	31.9	LOC152573	31.2	SFTPB
40.5	LOC402110	32.6	ELF3	32.5	COL6A3	31.4	S100A14
43.1	LOC653600	34.4	CLDN4	32.9	TIMP3	33.1	FOLR1
43.5	N/A	34.9	DCN	33.5	FOS	33.4	CDH5
50.7	MGC45438	35.7	CTGF	34.4	KRT19	34.9	CAV1
		35.7	MMP2	34.7	INHBA	35.4	DLC1
		36.2	MFAP4	35.2	HP	35.6	FOSB
		37.1	EPB42	35.6	CD177	36.1	KRT19
		37.2	H19	36.5	LCN2	36.4	SUSD2
		37.3	ATP1B1	36.9	CTGF	36.9	FN1
		37.5	INHBA	37.9	MMP8	37.2	ADH1C
		38.0	AZU1	38.3	ORM1	37.2	RNASE1
		38.5	LCN2	38.8	ELF3	37.3	IL1RL1
		39.6	CEACAM8	38.9	DCN	41.1	FOLR1
		40.3	CALCA	39.0	CTSG	41.3	DHCR24
		41.4	LOC387763	39.1	CLDN4	41.3	LOC387763
		42.2	CEACAM3	39.3	CALCA	42.0	ADH1B
		45.9	UNQ473	40.0	DCN	43.6	LAMA3
		54.0	BPIL1	40.1	FOSB	45.0	GPX3
		56.2	FN1	41.1	ATP1B1	47.9	DCN
		56.7	CEACAM5	41.6	MFAP4	49.1	EPAS1
		58.4	MMP8	41.8	FN1	50.9	CNN3
		65.0	CALCA	42.0	MMP2	51.5	DCN
		66.3	BPI	42.0	GPR97	54.5	LOC653509
		68.7	DEFA1	42.2	INHBA	56.2	CXCL2
		72.3	COL1A2	45.5	AZU1	58.2	MGC45438
		77.2	CA1	46.0	BPI	58.5	CYP4B1
		80.2	PLUNC	46.4	LOC387763	59.3	CTGF
		83.0	CEACAM1	46.6	MPO	75.8	GPRC5A
		83.9	DEFA4	50.0	HP	88.9	TIMP3
		85.0	COL3A1	50.7	ORM2	149.5	MFAP4
		96.1	DEFA1	53.1	UNQ473
		99.4	CEACAM5	57.8	AQP9
		101.2	CEACAM1	59.6	CEACAM5
		115.8	LOC653600	59.6	BPIL1
		140.3	DEFA4	61.0	CEACAM1
				62.8	DEFA1
				66.5	CEACAM1
				72.6	DEFA4
				82.5	PLUNC
				86.7	DEFA1
				92.9	COL1A2
				100.8	CEACAM5
				101.1	CALCA
				109.4	LOC653600
				111.5	COL3A1
				165.7	DEFA4

^aData are from patients with stable chronic obstructive pulmonary disease (Stable) or acute exacerbation of chronic obstructive pulmonary disease on day 1 (AE-1), day 3 (AE-3) and day 10 (AE-10) of hospital admission, as compared to healthy controls.

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