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Table 4 Goodness criteria of presepsin for diagnosis of sepsis, severe sepsis and septic shock during the first week of ICU treatment

From: Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment

  Area under the curve Cutoff, pg/ml Accuracy, % Sensitivity, % Specificity, % PPV, % NPV, % Relative risk P-value
Day 1          
≥ Septic shock 0.80 700 82 91 (67/74) 77 (78/102) 74 (67/91) 92 (78/85) 8.9 0.0001
Day 3          
≥ Sepsis 0.84 530 86 90 (73/81) 60 (09/15) 93 (73/79) 56 (09/16) 2.1 0.0001
≥ Severe sepsis 0.80 600 80 91 (61/67) 54 (15/28) 82 (61/74) 71 (15/21) 2.9 0.0001
Day 8          
≥ Sepsis 0.82 530 76 94 (45/48) 46 (13/28) 75 (45/60) 81 (13/16) 4.0 0.001
≥ Severe sepsis 0.77 600 66 92 (34/37) 41 (16/39) 60 (34/57) 84 (16/19) 3.8 0.001
≥ Septic shock 0.79 700 50 89 (16/18) 38 (22/58) 31 (16/52) 92 (22/24) 3.7 0.03
  1. Diagnostic goodness criteria have only been calculated when the diagnostic AUC was ≥0.75. PPV and NPV: positive and negative predictive values. Values in brackets represent the following: sensitivity (true positives/all diseased); specificity (true negatives / all non diseased); PPV (true positives/all test positives); NPV (true negatives/all test negatives).