Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment

Table 4 Goodness criteria of presepsin for diagnosis of sepsis, severe sepsis and septic shock during the first week of ICU treatment

	Area under the curve	Cutoff, pg/ml	Accuracy, %	Sensitivity, %	Specificity, %	PPV, %	NPV, %	Relative risk	P-value
Day 1
≥ Septic shock	0.80	700	82	91 (67/74)	77 (78/102)	74 (67/91)	92 (78/85)	8.9	0.0001
Day 3
≥ Sepsis	0.84	530	86	90 (73/81)	60 (09/15)	93 (73/79)	56 (09/16)	2.1	0.0001
≥ Severe sepsis	0.80	600	80	91 (61/67)	54 (15/28)	82 (61/74)	71 (15/21)	2.9	0.0001
Day 8
≥ Sepsis	0.82	530	76	94 (45/48)	46 (13/28)	75 (45/60)	81 (13/16)	4.0	0.001
≥ Severe sepsis	0.77	600	66	92 (34/37)	41 (16/39)	60 (34/57)	84 (16/19)	3.8	0.001
≥ Septic shock	0.79	700	50	89 (16/18)	38 (22/58)	31 (16/52)	92 (22/24)	3.7	0.03

Diagnostic goodness criteria have only been calculated when the diagnostic AUC was ≥0.75. PPV and NPV: positive and negative predictive values. Values in brackets represent the following: sensitivity (true positives/all diseased); specificity (true negatives / all non diseased); PPV (true positives/all test positives); NPV (true negatives/all test negatives).

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