Table 1 Baseline characteristics of the Mannheim Sepsis Study (MaSep)

Age, years (mean, range)

62 (42 to 87)

74 (61 to 81)

66 (50 to 81)

66 (26 to 87)

68 (26 to 88)

Gender, n (%)

Male

29 (48)

5 (56)

4 (80)

21 (75)

52 (70)

Female

31 (52)

4 (44)

1 (20)

7 (25)

22 (30)

Lung

-

-

5 (100)

20 (71)

41 (55)

Urinary tract

-

-

-

3 (11)

4 (5)

Abdominal

-

-

-

3 (11)

12 (16)

Central nervous system

-

-

-

-

-

Skin

-

-

-

1 (4)

3 (4)

Heart

-

-

-

-

-

Neutropenia

-

-

-

-

-

Blood

-

-

-

1 (4)

7 (10)

Others

-

-

-

-

7 (10)

White blood cells, 10⁹/L

-

14.5 ± 1.7

19.2 ± 3.1

17.4 ± 3.1

19.5 ± 1.8

Platelets, 10⁹/L

-

210 ± 216

305 ± 202

218 ± 214

191 ± 142

Bilirubin, mg/dl

-

0.8 ± 0.2

0.5 ± 0.1

1.1 ± 0.3

2.9 ± 0.7

Creatinine, mg/dl

-

1.1 ± 0.1

1.2 ± 0.2

2.4 ± 0.3

2.7 ± 0.2

C-reactive protein, mg/L

-

68 ± 16

155 ± 28

178 ± 24

197 ± 12

Procalcitonin, ng/ml

-

2.0 ± 0.9

4.3 ± 2.8

6.9 ± 2.0

22.2 ± 4

Interleukin 6, pg/ml

-

335 ± 154

142 ± 53

1,385 ± 829

21,089 ± 15,437

pCO2, mmHg

-

43 ± 5

49 ± 14

45 ± 4

44 ± 2

Positive blood cultures, n (%)

-

0 (0)

0 (0)

8 (29)

25 (34)

ICU days

-

10 ± 2

8 ± 2

10 ± 2

15 ± 2

Ventilation days

-

3 ± 1

4 ± 2

6 ± 2

9 ± 2

Catecholamine days

-

2 ± 1

0 ± 0

2 ± 1

7 ± 1

Renal replacement therapy days

-

0 ± 0

0 ± 0

1 ± 0.6

3 ± 1

APACHE II, mean ± SEM

-

24 ± 2

18 ± 3

20 ± 2

27 ± 1

SOFA score, mean ± SEM

-

7.6 ± 1.1

6.2 ± 1.8

6.1 ± 0.5

11.8 ± 0.4

All-cause mortality, n (%)

30 days

Death

0 (0)

4 (44)

2 (40)

10 (36)

42 (57)

Survivor

60 (100)

5 (56)

3 (60)

18 (64)

32 (43)

6 months

Death

0 (0)

4 (44)

3 (60)

12 (43)

53 (72)

Survivor

60 (100)

5 (56)

2 (40)

16 (57)

21 (28)