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Table 3 Histologic findings

From: Non-lobar atelectasis generates inflammation and structural alveolar injury in the surrounding healthy tissue during mechanical ventilation

VT20/ZEEP

Peri-atelectasis

Control

P-value

Alveolar disruption

1.3 (0.7 to 2.2)

1 (0.6 to 1.2)

<0.05

Neutrophil infiltration

3 (2 to 3)

1 (1 to 3)

<0.05

Interstitial edema

2.2 (1.4 to 2.6)

1.1 (0.9 to 1.2)

<0.05

Hemorrage

1.5 (0.9 to 2)

1.1 (1 to 2)

0.6

VT10/PEEP3

   

Alveolar disruption

1.7 (1 to 2.2)

1.1 (0.9 to 1.2)

<0.05

Neutrophil infiltration

3 (2 to 3)

2 (1 to 2)

<0.05

Interstitial edema

2.4 (1.7 to 2.7)

1.1 (0.8 to 2.1)

0.06

Hemorrage

1.2 (1.1 to 2)

1.7 (0.8 to 2)

0.6

TOTAL

   

Alveolar disruption

1.4 (0.7 to 2.2)

1 (0.6 to 1.2)

<0.05

Neutrophil infiltration

3 (1 to 3)

1.5 (3 to 1)

<0.05

Interstitial edema

2.3 (1.4 to 2.7)

1.1 (0.8 to 2.1)

<0.05

Hemorrage

1.5 (0.9 to 2)

1.4 (0.8 to 2)

0.6

  1. VT20/ZEEP: tidal volume = 20 mL/kg and zero end-expiratory pressure (PEEP = 0 cmH2O); VT10/PEEP3: tidal volume = 10 mL/kg and positive end-expiratory pressure = 3 cmH2O. Peri-atelectasis and Control represent peri-atelectasis and contralateral lung regions, respectively. Data are expressed as median and range.