Table 1 Patient characteristics and variables according to ScvO 2 -guided therapies
| Â | Entire cohort (n = 572) | Inotrope administered (n = 238) | RBCs transfused (n = 71) | No intervention (n = 275) |
|---|---|---|---|---|
Demographics and comorbidities | ||||
Age, years | 73 (62-82) | 76 (65-83) | 70 (61-81) | 71 (60-81) |
Female (%) | 46.7 | 47.1 | 46.5 | 46.2 |
Race | Â | Â | Â | Â |
White (%) | 57.9 | 57.1 | 49.3 | 59.6 |
Asian (%) | 13.5 | 15.5 | 14.1 | 12.0 |
Hispanic (%) | 12.9 | 11.8 | 14.1 | 13.5 |
African-American (%) | 8.2 | 7.6 | 14.1 | 7.6 |
Other (%) | 7.5 | 8.0 | 8.4 | 7.3 |
Ischemic heart disease (%) | 31.3 | 30.7 | 38.0 | 30.2 |
Congestive heart failure (%) | 36.4 | 39.5 | 32.4 | 34.2 |
Chronic lung disease (%) | 34.1 | 30.7 | 26.7 | 38.9 |
Diabetes (%) | 34.8 | 34.4 | 26.7 | 37.1 |
HIV/AIDS (%) | 0.9 | 0.4 | 1.4 | 1.1 |
Malignancy (%) | 14.9 | 12.2 | 32.4 | 13.1 |
Rheumatologic disease (%) | 6.3 | 5.0 | 9.9 | 6.5 |
Elixhauser score | 16 (8-23) | 16 (10-22) | 19 (11-28) | 15 (7-23) |
Initial presenting variables | ||||
Systolic blood pressure, mm Hga | 109 (92-129) | 109 (92-129) | 102 (86-113) | 112 (93-132) |
Diastolic blood pressure, mm Hga | 63 (52-76) | 63 (50-76) | 56 (44-68) | 64 (53-77) |
Heart rate, bpma | 109 (92-125) | 108 (91-124) | 118 (99-130) | 108 (90-124) |
Shock indexa | 1.0 (0.8-1.2) | 1.0 (0.8-1.2) | 1.1 (0.9-1.4) | 1.0 (0.8-1.2) |
Initial serum lactate, mmol/Lb | 4.4 (3.0-6.2) | 4.5 (3.2-6.3) | 4.4 (3.6-7.7) | 4.3 (2.8-6.0) |
Positive blood cultures (%) | 35.3 | 35.7 | 49.3 | 32.4 |
EGDT treatment period variables | ||||
Fluid administered by 6 hours, liters | 4.0 (3.0-5.0) | 4.0 (3.0-5.1) | 4.1 (3.0-5.0) | 4.0 (2.6-5.0) |
Peak CVP, mm Hgb | 16 (13-21) | 16 (13-21) | 15 (12-19) | 16 (13-22) |
Hemoglobin nadir, g/dLb | 11.4 (9.5-13.2) | 12.1 (10.3-13.6) | 7.9 (7.1-8.8) | 11.3 (10.0-13.1) |
Antibiotic therapy within one hour (%) | 93.4 | 94.5 | 95.8 | 91.6 |
Mechanical ventilation (%)b | 32.5 | 32.4 | 31.0 | 32.7 |
Vasopressor administration (%)b | 58.6 | 72.7 | 62.0 | 46.2 |
Initial ScvO2, percentb | 63 (55-69) | 62 (55-69) | 61 (55-68) | 64 (57-69) |
Final ScvO2, percentb | 68 (61-73) | 68 (62-73) | 70 (60-75) | 67 (61-72) |
Final ScvO2 > 70% (%) | 43.5 | 46.6 | 51.3 | 39.4 |
Lactate clearance, percent per hourb | 8.4 (4.5-12.9) | 8.3 (4.2-12.6) | 9.5 (3.6-13.0) | 8.3 (4.5-13.0) |
Lactate clearance >5% per hour (%) | 72.5 | 72.5 | 72.4 | 71.8 |
mSOFA score at 6 hours | 4 (3-6) | 5 (4-7) | 5 (3-6) | 4 (2-6) |
eSAPS 3 score | 50 (44-57) | 52 (46-58) | 52 (45-59) | 48 (43-55) |
Post-treatment variables | ||||
mSOFA score at 24 hours | 5 (3-7) | 5 (4-7) | 5 (3-7) | 4 (3-6) |
In-hospital mortality (%) | 20.5 | 22.7 | 18.3 | 19.3 |