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Table 1 Patient characteristics and variables according to ScvO 2 -guided therapies

From: In-hospital mortality following treatment with red blood cell transfusion or inotropic therapy during early goal-directed therapy for septic shock: a retrospective propensity-adjusted analysis

  Entire cohort (n = 572) Inotrope administered (n = 238) RBCs transfused (n = 71) No intervention (n = 275)
Demographics and comorbidities
Age, years 73 (62-82) 76 (65-83) 70 (61-81) 71 (60-81)
Female (%) 46.7 47.1 46.5 46.2
Race     
White (%) 57.9 57.1 49.3 59.6
Asian (%) 13.5 15.5 14.1 12.0
Hispanic (%) 12.9 11.8 14.1 13.5
African-American (%) 8.2 7.6 14.1 7.6
Other (%) 7.5 8.0 8.4 7.3
Ischemic heart disease (%) 31.3 30.7 38.0 30.2
Congestive heart failure (%) 36.4 39.5 32.4 34.2
Chronic lung disease (%) 34.1 30.7 26.7 38.9
Diabetes (%) 34.8 34.4 26.7 37.1
HIV/AIDS (%) 0.9 0.4 1.4 1.1
Malignancy (%) 14.9 12.2 32.4 13.1
Rheumatologic disease (%) 6.3 5.0 9.9 6.5
Elixhauser score 16 (8-23) 16 (10-22) 19 (11-28) 15 (7-23)
Initial presenting variables
Systolic blood pressure, mm Hga 109 (92-129) 109 (92-129) 102 (86-113) 112 (93-132)
Diastolic blood pressure, mm Hga 63 (52-76) 63 (50-76) 56 (44-68) 64 (53-77)
Heart rate, bpma 109 (92-125) 108 (91-124) 118 (99-130) 108 (90-124)
Shock indexa 1.0 (0.8-1.2) 1.0 (0.8-1.2) 1.1 (0.9-1.4) 1.0 (0.8-1.2)
Initial serum lactate, mmol/Lb 4.4 (3.0-6.2) 4.5 (3.2-6.3) 4.4 (3.6-7.7) 4.3 (2.8-6.0)
Positive blood cultures (%) 35.3 35.7 49.3 32.4
EGDT treatment period variables
Fluid administered by 6 hours, liters 4.0 (3.0-5.0) 4.0 (3.0-5.1) 4.1 (3.0-5.0) 4.0 (2.6-5.0)
Peak CVP, mm Hgb 16 (13-21) 16 (13-21) 15 (12-19) 16 (13-22)
Hemoglobin nadir, g/dLb 11.4 (9.5-13.2) 12.1 (10.3-13.6) 7.9 (7.1-8.8) 11.3 (10.0-13.1)
Antibiotic therapy within one hour (%) 93.4 94.5 95.8 91.6
Mechanical ventilation (%)b 32.5 32.4 31.0 32.7
Vasopressor administration (%)b 58.6 72.7 62.0 46.2
Initial ScvO2, percentb 63 (55-69) 62 (55-69) 61 (55-68) 64 (57-69)
Final ScvO2, percentb 68 (61-73) 68 (62-73) 70 (60-75) 67 (61-72)
Final ScvO2 > 70% (%) 43.5 46.6 51.3 39.4
Lactate clearance, percent per hourb 8.4 (4.5-12.9) 8.3 (4.2-12.6) 9.5 (3.6-13.0) 8.3 (4.5-13.0)
Lactate clearance >5% per hour (%) 72.5 72.5 72.4 71.8
mSOFA score at 6 hours 4 (3-6) 5 (4-7) 5 (3-6) 4 (2-6)
eSAPS 3 score 50 (44-57) 52 (46-58) 52 (45-59) 48 (43-55)
Post-treatment variables
mSOFA score at 24 hours 5 (3-7) 5 (4-7) 5 (3-7) 4 (3-6)
In-hospital mortality (%) 20.5 22.7 18.3 19.3
  1. Continuous values are presented as median values with interquartile ranges in parentheses. Dichotomous variables are presented as percentages. aAt initial emergency department presentation; bwithin the first six hours from shock recognition (time zero). ScvO2, central venous oxygen saturation; RBC, red blood cells; HIV/AIDS, human immunodeficiency virus/acquired immunodeficiency syndrome; mm Hg, millimeters mercury; bpm, beats per minute; EGDT, early goal-directed therapy; CVP, central venous pressure; g/dL, grams per deciliter; mSOFA, modified sequential organ failure assessment score; eSAPS, electronic simplified acute physiology score.